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MILabs announces Image of the Year Awards at WMIC 2019
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MILabs has selected winners for its annual preclinical Image of the Year awards at the World Molecular Imaging Congress (WMIC) in Montreal, Canada. Entries were judged on scientific merit, the type of information gleaned from the images, and overall image quality. All images were judged by a panel of independent experts.
“This year’s winners represent breakthrough research in animal PET, SPECT, Optical and CT imaging by our users and cover applications in oncology, neurology, immunology, in vivo histology, bone morphometry, cardiology, metabolic and pulmonary research, plus the burgeoning field of immunotherapy,” said Frederik Beekman Ph.D., CEO and Founder of MILabs. “We congratulate the winners of this year’s competition and are grateful to all our users for their tireless effort and dedication to the field of preclinical research.”
The honorees are:
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Neurology I: Mouse model shows how Parkinson’s Disease begins in the gut
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Johns Hopkins University School of Medicine, Baltimore
S. Kim, S.H. Kwon, T.I. Kam, N. Panicker, S.S. Karuppagounder, S. Lee, J.H. Lee, W.R. Kim, M. Kook, C.A. Foss, C. Shen, H. Lee, S. Kulkarni, P.J. Pasricha, G. Lee, M.G. Pomper, V.L. Dawson, T.M. Dawson, H.S. Ko;
Neuron, June 2019
Loss of dopamine neurons following PFF ( preformed fibril) injection into the gut shown with DAT-scan using U-SPECT/CT
Read full paper here.
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Neurology II: Restoration of brain circulation and cellular functions hours post-mortem
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Yale School of Medicine, New Haven
Z. Vrselja, S. Daniele, J. Silbereis, F. Talpo, Y. M. Morozov, A. M. Sousa, B. S. Tanaka, M. Skarica, M. Pletikos, N. Kaur, Z. W. Zhuang, Z. Liu, R. Alkawadri, A. J. Sinusas, S. R. Latham, S. Waxman & N. Sestan;
Nature, April 2019
CT angiography of an intact pig brain perfused under ex vivo normothermic conditions. Obtained by the CT modality of a U-SPECT/CT.
Read full paper here.
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Oncology: Simultaneous PET/SPECT of co-injected tracers allows in vivo PET immunohistochemistry
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University of Oxford, Institute for Radiation Oncology
J.C. Knight, M.J. Mosley, V. Kersemans, G.M. Dias, P.D. Allen, S. Smart, B. Cornelissen;
Nucl Med Biol., March 2019
The dual-isotope PET/SPECT method of the VECTor described herein provides a quantitative and highly personalized value of epitope-specific uptake for antibody-based radiopharmaceuticals.
Read full paper here.
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Cardiovascular: Imaging cardiovascular gene therapy with nuclear reporters
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Yale School of Medicine, New Haven.
Boutagy N, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ
Circulation Cardiac Imaging. July 2019
U-SPECT/CT imaging of NIS-mediated 99mTcO4− uptake enables accurate and sensitive in vivo quantification of AVV9-mediated gene expression
Read full paper here.
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Optical Tomography: 3D FLT/CT tracks intracranial injection and visualizes BBB permeability
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Columbia University PET Center, New York.
Molotkov A, Doubrovin M, Mintz A, Poster,
WMIC 2019, Montreal, Canada, September 2019
Pinpoint visualization of intracranial injection spot using 3D optical scanner with microCT. Solution of mouse albumin labeled with Cy7 (mALB-Cy7) was injected intracranially into brain of a normal mouse. 3D optical image was obtained using MILabs FLT/CT scanner 24h after mALB-Cy7 injection.
Read full paper here.
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Theranostics I: Enchancing treatment efficacy of 177Lu-PSMA
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BC Cancer Research Centre, Vancouver.
Kuo HT, Merkens H, Zhang Z, Uribe CF, Lau J, Zhang C, Colpo N, Lin KS, Benard F;
Mol Pharm. September 2018
These U-SPECT/CT images demonstrate that a novel albumin-binder-conjugated 177Lu-PSMA-617 derivative, 177Lu-HTK01169, has an extended blood retention time to maximize the radiation dose delivered to prostate tumors expressing prostate-specific membrane antigen (PSMA).
Read full paper here.
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Theranostics II: First whole-body 3D tomographic imaging of alpha particle emitting Radium-223
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Washington University School of Medicine, St. Louis.
Diane S. Abou, Andrew Rittenbach, Ryan E. Tomlinson, Paige A. Finley, Benjamin Tsui, Brian W. Simons, David Ulmert, Ryan C. Riddle, Daniel LJ Thorek;
bioRxiv, September 2018
Whole-body in vivo 223Ra alpha-therapy imaging with VECTor/CT to enable quantitative assessment of 223Ra distribution, which may provide radiation dose optimization strategies to improve therapeutic response.
Read full paper here.
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MoBi, September 26-27, Münster
EANM, October 12-16, Barcelona
ISTR, October 28-November 1, Vienna
Dutch Life Sciences, November 28, Leiden
RSNA, December 1-7, Chicago
ORS, February 8-11, Phoenix
AACR, April 24-29, San Diego
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