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Scientific Articles 2017-07-20T14:12:16+00:00

Selected journal papers

Exciting applications of MILabs imaging equipment.

  • 18F-FDG as an inflammation biomarker for imaging dengue virus infection and treatment response, AM. Chacko, S. Watanabe, K.J. Herr, S. Kalimuddin, JY. Tham, J. Ong, M. Reolo, R.M.F. Serrano, YB. Cheung, J.G.H. Low, and S.G. Vasudevan, JCI insight, 2017 May, PubMed Link
  • Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan.  Joosten, M. Brom, M.K.H. Schäfer, O.C. Boerman, E. Weihe, M. Gotthardt. Sci Rep. 2017 May. PubMed Link
  • Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors.A. Slastnikova, A.A. Rosenkranz, Y.V. Khramtsov, T.S. Karyagina, S.A. Ovechko, A.S. Sobolev.Drug Des Devel Ther. 2017 Apr. PubMed Link
  • Multi-isotope SPECT imaging of the 225Ac decay chain: feasibility studies. K. Robertson, C. Ramogida, C. Rodriguez-Rodriguez, S. Blinder, P. Kunz, V. Sossi, P. Schaffer. Phys Med Biol. 2017 Mar. PubMed Link
  • Hybrid Imaging Labels: Providing the Link Between Mass Spectrometry-Based Molecular Pathology and Theranostics.  Buckle, S. van der Wal, S.J. van Malderen, L. Müller, J. Kuil, V.  van Unen, R.J. Peters, M.E. van Bemmel, L.A. McDonnell, A.H. Velders, F. Koning, F. Vanhaeke, F.W. van Leeuwen. Theranostics. 2017 Jan. PubMed Link 
  • Iminodiacetic acid as bifunctional linker for dimerization of cyclic RGD peptides.
    Xu, Z.Q. Zhao, S.T. Chen, Y. Yang, W. Fang, S. Liu.Nucl Med Biol. 2017 Jan . PubMed Link
  • Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters.A. Slastnikova, A.A. Rosenkranz, N.B. Morozova, M.S. Vorontsova, V.M. Petriev, T.N. Lupanova, A.V. Ulasov, M.R. Zalutsky,  R.I. Yakubovskaya, A.S. Sobolev. Int J Nanomedicine. 2017 Jan. PubMed Link
  • Detection of micrometastases using SPECT/fluorescence dual-modality imaging in a CEA-expressing tumor model. C. Hekman, M. Rijpkema, D. Bos,  E. Oosterwijk, D.M. Goldenberg, P.F. Mulders, O.C. Boerman. J Nucl Med. 2017 Jan. PubMed Link
  • High-resolution 4D pre-clinical SPECT/CT imaging of technetium transport within a heterogeneous porous media. Dogan, S.M.J. Moysey, R.M. Ramakers, T.A. DeVol, F.J. Beekman, H.C. Groen, B.A. Powell. Environ. Sc. Technol. 2017 Jan. PubMed Link
  • 188Re image performance assessment using small animal multi-pinhole SPECT/PET/CT system. L. Esquinas, C. Rodríguez-Rodríguez, J. Carlos De La Vega, M. Bokharaei, K. Saatchi, M. Shirmohammad, U.O. Häfeli, V. Sossi, A.Celler. Phys Med. 2016 Dec. PubMed Link
  • A single-scan protocol for absolute D2/3 receptor quantification with [123I]IBZM SPECT.  Tsartsalis, B.B. Tournier, K. Aoun, S. Habiby, D. Pandolfo, A. Dimiziani, N. Ginovart, P. Millet. Neuroimage. 2016 Dec. Pubmed Link
  • In Vivo Simultaneous Imaging of Vascular Pool and Hypoxia with a HT-29 Tumor Model: the Application of Dual-Isotope SPECT/PET/CT. N. Adachi, Y. Yoshii, T/ Furukawa, M. Yoshimoto, Y. Takeuchi, M. Inubushi, H, Wakizaka, M, Zhang, A.B. Tsuji, M. Takahashi, Y. Fujibayashi, and T. Saga. International Journal of Sciences: Basic and Applied Research (IJSBAR). 2016  Direct Link
  • Quantitative and longitudinal imaging of intramuscular transplanted islets of Langerhans with SPECT using [123 I]IBZM. M. Willekens, I. van der Kroon, D. Bos, L. Joosten, C. Frielink, O.C. Boerman, M Brom, M. Gotthardt.  Diabetes Obes Metab. 2016 Dec. PubMed Link
  • Ultra-Small Biocompatible Bi2Se3 Nanodots for Multimodal-Imaging-Guided Synergistic Radio-Photothermal Therapy against Cancer. Mao, L. Wen, C. Sun, S. Zhang, G. Wang, J. Zeng, Y. Wang, J. Ma, M. Gao, Z. Li.ACS Nano 2016 Nov. Direct Link
  • 99mTc-Duramycin SPECT imaging of early tumor response to targeted therapy: a comparison with 18F-FDG PET.  Elvas, J. Boddaert, C. Vangeste, K. Pak, B. Gray, S. Kumar-Singh, S. Staelens, S. Stroobants, L. Wyffels.J. Nucl. Med. 2016 Nov. Pubmed Link
  • Novel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) as potential radiotracers for heart imaging. Liu, Y. Zheng, U. Avcibasi, S. Liu. Nuclear Medicine and Biology 2016 Nov. Pubmed Link
  • Comparison of biological properties of 99mTc-labeled cyclic RGD Peptide trimer and dimer useful as SPECT radiotracers for tumor imaging.  Zhao, Y. Yang, W. Fang, S. Liu. Nucl. Med Biol. 2016 Nov. Pubmed Link
  • Novel 99mTc(III) Complexes [99mTcCl(CDO)(CDOH)2B-R] (CDOH2 = Cyclohexanedione Dioxime) Useful as Radiotracers for Heart Imaging. Liu, W. Fang, S. Liu,  Bioconjugate Chem. 2016 Oct. Pubmed Link
  • 68Ga/177Lu-NeoBOMB1, A Novel Radiolabeled GRPR Antagonist For Theranostic Use In Oncology. U. Dalm, I.L. Bakker, E. de Blois, G.N. Doeswijk, M.W. Konijnenberg, F. Orlandi, D. Barbato, M. Tedesco, T. Maina, B.A. Nock, M. de Jong. J Nucl Med. 2016 Sep. PubMed Link
  • Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy. Chao, G. Wang, C. Liang, X. Yi, X. Zhong, J. Liu, M. Gao, K. Yang, L. Cheng. Small 2016 Aug. Pubmed Link
  • Ambient Aqueous Synthesis of Ultra-small PEGylated Cu2−xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer. Zhang, C. Sun, J. Zeng, Q. Sun, G. Wang, Y. Wang, Y. Wu, S. Dou, M. Gao, and Z. Li. Advanced materials 2016 Aug. Pubmed Link
  • Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity.  Vangestel, D. Thomae, J. Van Soom, J. Ides, L. wyffels, P. Pauwels, S. Stroobants, P. Van der Veken, V. Magdolen, J. Joossens, K. Augustyns, S. Staelens.Contrast Media Mol Imaging 2016 Aug. Pubmed Link
  • Improved quantification of the beta cell mass after pancreas visualization with 99mTc-demobesin-4 and beta cell imaging with 111In-exendin-3 in rodents.  van der Kroon, L. Joosten, B.A. Nock, T. Maina, O.C. Boerman, M. Brom, M. Gotthardt. Mol. Pharm 2016 Aug. Pubmed Link
  • In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage mediated clearance from the bone marrow.  T. van der Meer, S.Y.A. Terry, D. van Ingen Schenau, K.C. Andree, G.M. Franssen, D.M. Roeleveld, B.M. Metselaar, T. Reinheckel, P.M. Hoogerbrugge, O.C. Boerman, F.N. van Leeuwen.J Nucl Med. 2016 Aug. Pubmed Link
  • Liposomal treatment of experimental arthritis can be monitored non-invasively with radiolabeled anti-FAP antibodies.  van der Geest, P. Laverman, D. Gerrits, B. Walgreen, M.H. Helsen, C. Klein, T.K. Nayak, G. Storm, J.M. Metselaar, M.I. Koenders, O.C. Boerman.J Nucl Med. 2016 Aug. Pubmed Link
  • Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers.  Wen, L. Chen, S. Zheng, J. Zeng, G. Duan, Y. Wang, G. Wang, Z. Chai, Z. Li, M. Gao. Advanced materials 2016 Aug. Pubmed Link
  • Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function.  Neyt, M. Vliegen, B. Verreet, S. De Lombaerde, K. Braeckman, C. Vanhove, M.T. Huisman, C. Dumolyn, K. Kersemans, F. Hulpia, S. Van Calenbergh, G. Mannens, F. De Vos.Nucl Med Biol. 2016 Jul. Pubmed Link
  • Left ventricular function measurements in a mouse myocardial infarction model. Comparison between 3D-echocardiography and ECG-gated SPECT.  Hendrikx, M. Bauwens, R. Wierts, F.M. Mottaghy, M.J. Post. Nuklearmedizin. 2016 Jun. Pubmed Link
  • Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging. A. Stammes, V.T. Knol-Blankevoort, L.J. Cruz, H.R.I.J. Feitsma, L. Mezzanotte, R.A. Cordfunke, R. Sinisi, E.A. Dubikovskaya, A. Maeda, R.S. DaCosta, K. Bierau, A. Chan, E.L. Kaijzel, T.J.A. Snoeks, E.R. van Beek, C.W.G.M. Löwik. Mol. Imaging Biol. 2016 Jun. Pubmed Link
  • In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT.  Jennings, O. Ivashchenko, I.J. Marsman, A.C. Laan, A.G. Denkova, G. Waton, F.J. Beekman, F. Schosseler, E. Mendes.Biomater Sci. 2016 Jun. Pubmed Link
  • High-resolution clustered-pinhole 131Iodine SPECT imaging in mice.  van der Have, O. Ivashchenko, M.C. Goorden, R.M. Ramakers, F.J. Beekman.Nuclear Medicine and Biology. 2016 Jun. Pubmed Link
  • Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent. L.S. Chatalic, S. Heskamp, M. Konijnenberg, J. Molkenboer-Kuenen, G.M. Franssen, M.C. Clahsen-van Groningen, M, Schottelius, H. Wester, W.M. van Weerden, O.C. Boerman, M. de Jong. Theranostics. 2016 Jun. Pubmed Link
  • Similarity-regulation of OS-EM for accelerated SPECT reconstruction. E. Vaissier, F.J. Beekman, M.C. Goorden. Phys Med Biol. 2016 Jun. Pubmed Link
  • Comparison of LDPI to SPECT perfusion imaging using (99m)Tc-sestamibi and (99m)Tc-pyrophosphate in a murine ischemic hind limb model of neovascularization. G. Hendrikx, M.H. Vries, M. Bauwens, M. De Saint-Hubert, A. Wagenaar, J. Guillaume, L. Boonen, M.J. Post, F.M. Mottaghy. EJNMMI Res.  2016 May. Pubmed Link
  • Radiolabeled cyclic RGD peptides as radiotracers for tumor imaging.  Shi, F. Wang, S. Liu.Biophys Rep. 2016 Apr. PubMed Link
  • SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments.A. Eter, S. Parween, L. Joosten, C. Frielink, M. Eriksson, M. Brom, U. Ahlgren,  M. Gotthardt. Sci Rep. 2016 Apr. Pubmed Link
  • Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography.  Lalut, B.B. Tournier, T. Cailly, C. Lecoutey, S. Corvaisier, A. Davis, C. Ballandonne, M. Since, P. Millet, F. Fabis, P. Dallemagne, C. Rochais. Eur J Med Chem. 2016 Mar. Pubmed Link
  • Optimizing modelling in iterative image reconstruction for preclinical pinhole PET, C. Goorden, J. van Roosmalen, F. van der Have, F.J. Beekman. Physics in medicine and biology 2016  Apr. Pubmed Link
  • Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging.  Kanazaki, K. Sano, A. Makino, F. Yamauchi, A. Takahashi , T. Homma, M. Ono, H. Saji. J Control Release. 2016 Feb. Pubmed Link
  • SPECT/CT imaging of Pluronic nanocarriers with varying PEO block length and aggregation state.  Arranja, O. Ivashchenko, A. Denkova, K. Morawska, S. van Vlierberghe, P. Dubruel, G. Waton, F. Beekman, F. Schosseler, E. Mendes.Mol Pharm. 2016 Feb, Pubmed Link
  • Early prediction of tumor response to treatment: pre-clinical validation of 99mTc-duramycin.  Elvas, C. Vangestel, K.Y. Pak, P. Vermeulen, B. Gray, S. Stroobants, S. Staelens, L. Wyffels.J Nucl Med. 2016 Feb. Pubmed Link
  • Noninvasive imaging of islet transplants with 111In-exendin-3 SPECT/CT.  van der Kroon I, K. Andralojc, S.M. Willekens, D. Bos, L. Joosten, O. Boerman, M. Brom, M. Gotthardt.J Nucl Med. 2016 Jan. Pubmed Link
  • Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia.  Shen, M.M. Patnaik, A. Ruiz, S.J. Russell, K.W. Peng. Blood. 2015 Dec. Pubmed Link
  • Monitoring therapy response of experimental arthritis with radiolabeled tracers targeting fibroblasts, macrophages or integrin αvβ3. Y. Terry, M. Koenders, G. Franssen, T. Nayak, A. Freimoser-Grundschober, C. Klein, W. Oyen, O. Boerman, P. Laverman. J Nucl Med. 2015 Dec. Pubmed Link
  • Utilizing high-energy gamma photons for high-resolution 213Bi SPECT in mice.  de Swart, H.S. Chan, M.C. Goorden, A. Morgenstern, F. Bruchertseifer, F.J. Beekman, M. de Jong, M. Konijnenberg. J Nucl Med. 2015 DecPubmed Link
  • Imaging, Biodistribution, and Dosimetry of Radionuclide-Labeled PD-L1 Antibody in an Immunocompetent Mouse Model of Breast Cancer. Josefsson, J.R. Nedrow, S.Park, S. Ray Banerjee, A. Rittenbach, F.Jammes, B.Tsu, G. Sgouros. Cancer Research 2015 Nov. Pubmed Link
  • SPECT of transplanted islets of Langerhans by dopamine 2 receptor targeting in a rat model. M. Willekens, I. van der Kroon, L. Joosten, C.  Frielin, O.C. Boerman, S.A. van den Broek, M. Brom, M. Gotthardt. Mol Pharm. 2015 Nov. Pubmed Link
  • Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer.Xiaoyan Zhong, Kai Yang, Zhiliang Dong, Xuan Yi, Yong Wang, Cuicui Ge, Yuliang Zhao, Zhuang Liu, Advanced Functional Materials, 2015 Nov. Direct Link
  • Central delivery of iodine-125–labeled cetuximab, etanercept and anakinra after perispinal injection in rats: possible implications for treating Alzheimer’s disease. E. Roerink, R.J.M. Groen, G. Franssen, B. Lemmers-van de Weem, O.C. Boerman, J.W.M. van der Meer.Alzheimer’s Research and Therapy. 2015 Nov. Direct Link
  • Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin. W.A. Eter, D. Bos, C. Frielink, O.C. Boerman, M. Brom, M. Gotthardt. Sci Rep. 2015 Oct. Direct Link
  • 5-HT2A receptor SPECT imaging with [123I]R91150 under P-gp inhibition with tariquidar: More is better?  Tsartsalis, B.B. Tournier, T. Huynh-Gatz, N. Dumas, N. Ginovart, M. Moulin-Sallanon, P. Millet. Nucl Med Biol. 2015 Sept. Pubmed Link
  • Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers.  Kondo, T. Temma, Y. Shimizu, M. Ono, H. Saji. Biol. Pharm. Bull. 2015 Sept. Pubmed Link
  • Biodistribution of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing. S.A. Low, C.V. Galliford, J. Yang, P.S. Low, and J. Kopecek. Biomacromolecules 2015 Sept. Pubmed Link
  • Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake.  Rotman, M.M.Welling, M.L. van den Boogaard, L.G. Moursel, L.M. van der Graaf, M.A. van Buchem, S.M. van der Maarel, L. van der Weerd. Nucl Med Biol. 2015 Aug. Pubmed Link
  • Oncolytic measles virus as a novel therapy for malignant peripheral nerve sheath tumors. R. Deyle, D.Z. Escobar, K.W. Peng, D. Babovic-Vuksanovic. Gene. 2015 Jul. Pubmed Link
  • 111In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages. Y. Terry, O.C. Boerman, D. Gerrits, G.M. Franssen, J.M. Metselaar, S. Lehmann, W.J. Oyen, C.A. Gerdes, K. Abiraj.EJNMMol Imaging. 2015 May. Pubmed Link
  • Non-invasive imaging of tumor PD-L1 expression using radiolabeled anti-PD-L1 antibodies.  Heskamp, W. Hobo, J.D. Molkenboer-Kuenen, D. Olive, W.J. Oyen, H. Dolstra, O.C. Boerman.Cancer Res. 2015 May. Pubmed Link
  • Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET.Miwa, M. Inubushi, Y. Takeuchi, T. Katafuchi, M. Koizumi, T. Saga, M. Sasaki. Ann Nucl Med. 2015 Apr, Direct Link
  • Characterization of [(99m)Tc]Duramycin as a SPECT Imaging Agent for Early Assessment of Tumor Apoptosis. Elvas,  C. Vangestel, S. Rapic, J. Verhaeghe, B. Gray, K. Pak, S. Stroobants, S. Staelens, L. Wyffels. Mol Imaging Biol. 2015 Apr, Pubmed Link
  • ImmunoPET and immunoSPECT of rheumatoid arthritis with radiolabeled anti-fibroblast activation protein (FAP) antibody correlates with severity of arthritis.  Laverman, T. van der Geest, S.Y. Terry, D. Gerrits, B. Walgreen, M.M. Helsen, T.K. Nayak, A. Freimoser-Grundschober, I. Waldhauer, R.J. Hosse, E. Moessner, P. Umana, C. Klein, W.J. Oyen, M.I. Koenders, O.C. Boerman. J Nucl Med. 2015 Apr, Pubmed Link
  • Development of a hybrid tracer for SPECT & optical imaging of bacterial infections.  Welling, A. Bunschoten, J. Kuil, R. Nelissen, F.J. Beekman, T. Buckle, F.W. van Leeuwen. Bioconjug Chem. 2015 Apr, Pubmed Link
  • A Standardized Method for the Construction of Tracer Specific PET and SPECT Rat Brain Templates: Validation and Implementation of a Toolbox.  Vállez Garcia, C. Casteels, A.J. Schwarz, R.A. Dierckx, M. Koole, J. Doorduin.PLoS One. 2015 Mar, Pubmed Link
  • uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery. C. Boonstra, P.B. van Driel, D.M. van Willigen, M.A. Stammes, H.A. Prevoo, Q.R. Tummers, A.P. Mazar, F.J. Beekman, R.J. Kuppen, C.J. van de Velde, C.W. Löwik, J.V. Frangioni, F.W. van Leeuwen, C.F. Sier, A.L. Vahrmeijer.Oncotarget. 2015 Mar, Pubmed Link
  • SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.  Tsartsalis, N. Dumas, B.B. Tournier, T. Pham, M. Moulin-Sallanon, M. Grégoire, Y. Charnay, P. Millet. EJNMMI Research. 2015 Mar, Pubmed Link
  • 99m Tc Radiolabeling and Biological Evaluation of Nanoparticles Functionalized with a Versatile Coating Ligand.  Felber, M. Bauwens, J.M. Mateos, S. Imstepf, F.M. Mottaghy, R. Alberto. Chemistry. 2015 Mar, Pubmed Link
  • Design of a serotonin 4 receptor radiotracer with decreased lipophilicity for single photon emission computed tomography.  Fresneau, N. Dumas, B.B. Tournier, C. Fossey, C. Ballandonne, A. Lesnard, P. Millet, Y. Charnay, T. Cailly, J. Bouillon, F. Fabis. Eur J Med Chem. 2015 Mar, Pubmed Link
  • Radionuclide and fluorescence imaging of clear cell renal cell carcinoma using dual-labeled anti-Carbonic Anhydrase IX antibody G250. H. Muselaers, M. Rijpkema, D.L. Bos, J.F. Langenhuijsen, W.J. Oyen, P.F. Mulders, E. Oosterwijk, O.C. Boerman.J Urol 2015 Feb, Pubmed Link
  • 111In-cetuximab-F(ab’)2 SPECT and 18F-FDG PET for prediction and response monitoring of combined-modality treatment of human head and neck carcinomas in a mouse model. K. van Dijk, O.C. Boerman, G.M. Franssen, J.H.a.M. Kaanders, J. Bussink.J Nucl Med. 2015 Feb, Pubmed Link
  • Ultra-high-sensitivity sub-mm mouse SPECT.  Ivashchenko, F. van der Have, M.C. Goorden, R.M. Ramakers, F.J. Beekman.J Nucl Med. 2015 Feb, Pubmed Link
  • Molecular imaging of angiogenesis after myocardial infarction by (111)In-DTPA-cNGR and (99m)Tc-sestamibi dual-isotope myocardial SPECT.  Hendrikx, M. De Saint-Hubert, I. Dijkgraaf, M. Bauwens, K. Douma, R. Wierts, I. Pooters, N.M. Van den Akker, T.M. Hackeng, M.J. Post, F.M. Mottaghy. EJNMMI Res. 2015 Jan  Pubmed Link
  • Evaluation of a nonpeptidic ligand for imaging of cholecystokinin 2 receptor-expressing cancers. Wayua and P.S. Low. J Nucl Med. 2015 Jan, Pubmed Link
  • Impact of Boronate Capping Groups on Biological Characteristics of Novel 99mTc(III) Complexes [99mTcCl(CDO)(CDOH)2B-R].  Liu, Y. Zheng, Y. Yang, E. Tomaselli, W. Fang. J. Bioconjug Chem. 2015 Jan, Pubmed Link
  • Drug composition matters: the influence of carrier concentration on the radiochemical purity, hydroxyapatite affinity and in-vivo bone accumulation of the therapeutic radiopharmaceutical 188Rhenium-HEDP.  Lange, J.M. de Klerk, H.J. Bloemendal, R.M. Ramakers, F.J. Beekman, M.M. van der Westerlaken, N.H. Hendrikse, R. Ter Heine. Nucl Med Biol. 2015 Jan, Pubmed Link
  • Cetuximab-F(ab’)2-SPECT and FDG-PET for prediction and response monitoring of combined modality treatment of human head and neck carcinomas in a mouse model.K. van Dijk, O.C. Boerman, G.M. Franssen, J.H. Kaanders, J. Bussink. J Nucl Med. 2014 Dec. Pubmed Link
  • Noninvasive 3D imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene. D.Hickey, S.A. Mao, B. Amiot, L. Suksanpaisan, A. Miller, R. Nace, J. Glorioso, M.K. O’Connor, K.W. Peng, Y. Ikeda, S.J. Russell, S.L. Nyberg, Liver Transpl. 2014 Dec, Pubmed Link
  • Early Response Monitoring with 18F-FDG PET and Cetuximab-F(ab’)2-SPECT After Radiotherapy of Human Head and Neck Squamous Cell Carcinomas in a Mouse Model.K. van Dijk, O.C. Boerman, G.M. Franssen, J. Lok, J.H. Kaanders, J. Bussink, J Nucl Med. 2014 Oct, Pubmed Link
  • Folate Receptor-β Imaging Using 99mTc-Folate to Explore Distribution of Polarized Macrophage Populations in Human Atherosclerotic Plaque. A. Jager, J. Westra, R. Golestani, G.M. van Dam, P.S. Low, R.A. Tio, R.H.J.A. Slart, H.H. Boersma, M. Bijl, C.J. Zeebregts,J Nucl Med. 2014 Oct, Direct Link
  • Can 111In-RGD2 Monitor Response to Therapy in Head and Neck Tumor Xenografts? Y. Terry, K. Abiraj, J. Lok, D. Gerrits, G.M. Franssen, W.J. Oyen, O.C. Boerman, J Nucl Med. 2014 Oct,Pubmed Link
  • U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform. N. van Oosterom, R. Kreuger, T. Buckle, W. A. Mahn, A. Bunschoten, L. Josephson, F.W.B. van Leeuwen, F.J. Beekman,EJNMMI Research 2014 Oct, Pubmed Link
  • Combination of Single-Photon Emission Computed Tomography and Magnetic Resonance Imaging to Track 111In-Oxine-Labeled Human Mesenchymal Stem Cells in Neuroblastoma-Bearing Mice. Cusso, I. Mirones, S. Pena-Zalbidea, V. Garcia-Vazquez, J. Garcia-Castro, M. Desco, Mol. Imaging. 2014 Sept, Pubmed Link
  • Pretargeted dual-modality immuno-SPECT and near-infrared fluorescence imaging for image-guided surgery of prostate cancer.  Lütje, M. Rijpkema, D.M. Goldenberg, C.M. van Rij, R.M. Sharkey, W.J. McBride, G.M. Franssen, C. Frielink, W. Helfrich, W.J. Oyen, O.C. Boerman,Cancer Res. 2014 Sept, Pubmed Link
  • Quarter-mm resolution molecular mouse imaging with U-SPECT+ Ivashchenko, F. van der Have, J.L. Villena, H.C. Groen, R.M. Ramakers, H.H. Weinans, F.J. Beekman,Molecular Imaging 2014 Sept, Pubmed Link
  • In vivo and in vitro evidence that 99mTc-HYNIC-interleukin-2 is able to detect T lymphocytes in vulnerable atherosclerotic plaques of the carotid artery.W. Glaudemans, E. Bonanno, F. Galli, C.J. Zeebregts, E.F. de Vries, M. Koole, G. Luurtsema, H.H. Boersma, M. Taurino, R.H. Slart, A. Signore.Eur J Nucl Med Mol Imaging. 2014 Sept, Pubmed Link
  • Influence of Respiratory Gating, Image Filtering and Animal Positioning on High-Resolution ECG-Gated Murine Cardiac SPECT,  Wu, P.E.B. Vaissier, B. Vastenhouw, J.R. de Jong, R.H.J.A. Slart, F.J. Beekman,Molecular Imaging 2014 Sept, Pubmed Link
  • Impact of Multiple Negative Charges on Blood Clearance and Biodistribution Characteristics of 99mTc-Labeled Dimeric Cyclic RGD Peptides.  Yang, S. Ji, S. Liu, Bioconjug Chem. 2014 Aug. Pubmed Link
  • Development of kit formulations for 99m TcN-MPO: a cationic radiotracer for myocardial perfusion imaging. Zheng, S. Ji, E. Tomaselli, S. Liu, J Labelled Comp Radiopharm 2014 July. Pubmed Link
  • SPECT- and Fluorescence Image-Guided Surgery Using a Dual-Labeled Carcinoembryonic Antigen-Targeting Antibody,  Rijpkema, W.J. Oyen, D. Bos, G.M. Franssen, D.M. Goldenberg, O.C. Boerman, J Nucl Med 2014 July. Pubmed Link
  • Performance Assessment of a Preclinical PET Scanner with Pinhole Collimation by Comparison to a Coincidence-Based Small-Animal PET Scanner, D. Walker, M.C. Goorden, K. Dinelle, R.M. Ramakers, S. Blinder, M. Shirmohammad, F. van der Have, F.J. Beekman, V. Sossi, J Nucl Med 2014 Aug. Direct Link
  • Optimizing Lutetium 177–Anti–Carbonic Anhydrase IX Radioimmunotherapy in an Intraperitoneal Clear Cell Renal Cell Carcinoma Xenograft Model, H.J. Muselaers, E. Oosterwijk, D.L. Bos, W.J.G. Oyen, P.F.A. Mulders, O.C. Boerman, Mol Imaging, 2014 June. Pubmed Link
  • Oncolytic vaccinia virotherapy for endometrial cancer, P. Liu, J. Wang, V.A. Avanzato, J.N. Bakkum-Gamez, S.J. Russell, J.C. Bell, K.W. Peng,Gynecol Oncol. 2014 March. Direct Link
  • Optical Imaging of Renal Cell Carcinoma with Anti-Carbonic Anhydrase IX Monoclonal Antibody Girentuximab,H. Muselaers, A.B. Stillebroer, M. Rijpkema, G.M. Franssen, E. Oosterwijk, P.F. Mulders, W.J. Oyen, O.C. Boerman, J Nucl Med. 2014 April. Pubmed Link
  • In vivo molecular imaging of apoptosisand necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging, De Saint-Hubert, M. Bauwens, N. Deckers, M. Drummen, K. Douma, P. Granton, G. Hendrikx, D. Kusters, J. Bucerius, C.P. Reutelingsperger, F.M. Mottaghy, Mol Imaging Biol. 2014 April. Pubmed Link
  • Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody,  Lütje, M. Rijpkema, G.M. Franssen, G. Fracasso, W. Helfrich, A. Eek, W.J.Oyen, M. Colombatti, O.C. Boerman, J Nucl Med. 2014 April. Pubmed Link
  • Assessing Cardiac Injury in Mice With Dual Energy-MicroCT, 4D-MicroCT, and MicroSPECT Imaging After Partial Heart Irradiation, L. Lee, H. Min, N. Befera, D. Clark, Y. Qi, S. Das, G.A. Johnson, C.T. Badea, D.G. Kirsch, Int J Radiat Oncol Biol Phys. 2014 Mar.Pubmed Link
  • Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent,R. Ashton, N. Befera, D. Clark, Y. Qi, L. Mao, H.A. Rockman, G.A. Johnson, C.T. Badea, Contrast Media Mol Imaging. 2014 Mar. Pubmed Link
  • Dynamics of IGF-1R Expression During Endocrine Breast Cancer Treatment, Heskamp, O.C. Boerman, J.D. Molkenboer-Kuenen, R.H. Koornstra, S.C. Linn, W.J. Oyen, W.T. van der Graaf, H.W. van Laarhoven,Mol Imaging Biol. 2014 Feb 15. Pubmed Link
  • Imaging Integrin αvβ3 on Blood Vessels with 111In-RGD2 in Head and Neck Tumor Xenografts, Y. Terry, K. Abiraj, C. Frielink, L.K. van Dijk, J. Bussink, W.J. Oyen, O.C. Boerman, J Nucl Med. 2014 Feb.Pubmed Link
  • The role of preclinical SPECT in oncological and neurological research in combination with either CTor MRI, R. Bernsen, P.E.B. Vaissier, R. van Holen, J. Booij, F.J. Beekman, M. de Jong. Eur J Nucl Med Mol Imaging, April 2014. Direct Link
  • OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain, Kikuchi, T. Okamura, H. Wakizaka, M. Okada, K. Odaka, J. Yui, A.B. Tsuji, T. Fukumura, M.R. Zhang, J Cereb Blood Flow Metab. 2014 Feb 5, Pubmed Link
  • Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases.  ter Heine, R. Lange, O. B Breukels, H. J. Bloemendal, R. G Rummenie, A. M Wakker, H. de Graaf, F. J Beekman, M.  van der Westerlaken, M. M. Malingré, J.P.M. Wielders, L. van den Berge,  H. Hendrikse, J.M.H. de Klerk, Int. J. Pharmaceutics 2014, Pubmed Link
  • 3D histological validation of high-resolution SPECT of antibody distributions within xenografts.  Branderhorst, E.L.A. Blezer, M. Houtkamp, R.M. Ramakers, J. H. van den Brakel, H. Witteveen, F. van der Have, H. A. Gratama van Andel, B. Vastenhouw, M. Stigter-van Walsum, G.A.M.S. van Dongen, M. A. Viergever, W.K. Bleeker, F.J. Beekman.J. Nucl. Med. 2014, Direct Link
  • Small-Animal Single-Photon Emission Computed Tomographic Imaging of the Brain Serotoninergic Systems in Wild-Type and Mdr1a Knockout Rats,  Dumas, M. Moulin-Sallanon, N. Ginovart, B.B. Tournier, P. Suzanne, T. Cailly, F. Fabis, S. Rault, Y. Charnay, P. Millet, Molecular Imaging, 2014 Febr, Pubmed link.
  • SPECT vs. PET monitoring of bone defect healing and biomaterial performance in vivo, Ventura, G.M. Franssen, E. Oosterwijk, O.C. Boerman, J.A. Jansen, X.F. Walboomers,J Tissue Eng Regen Med. 2014 Jan, Pubmed link
  • Imaging of Epidermal Growth Factor Receptor Expression in Head and Neck Cancer with SPECT/CT and 111In-Labeled Cetuximab-F(ab9)2K. van Dijk, B.A.W. Hoeben, J.H.A.M. Kaanders, G.M. Franssen, O.C. Boerman, J. Bussink.J Nucl Med 2013 Oct, Pubmed Link
  • Microdistribution of MC1R-targeted polyplexes in murine melanoma tumor tissue, O. Durymanova, T.A. Slastnikovaa, A.I. Kuzmichd, Y.V. Khramtsova, A.V. Ulasova, A.A. Rosenkranza, S.Y. Egorovf, E.D. Sverdlovc, A.S. Sobolev, Biomaterials. 2013 Oct, Direct Link
  • Comparison of 4D-MicroSPECT and MicroCT for Murine Cardiac Function,T. Befera, C.T. Badea, G.A. Johnson, Mol. Imaging Biol. 2013 Sep, Direct Link
  • The strength of small: Improved targeting of Insulin-like Growth Factor-1 Receptor (IGF-1R) with F(ab’)2-R1507 fragments in Ewing sarcomas, D. Fleuren, Y.M. Versleijen-Jonkers, S. Heskamp, M.H. Roeffen, W.H. Bouwman, J.D. Molkenboer-Kuenen, H.W. van Laarhoven, W.J. Oyen, O.C. Boerman, W.T. van der Graaf.Eur J Cancer, 2013 Sep. Pubmed Link
  • Oral contrast enhances the resolution of in-life NIS reporter gene imaging, L Suksanpaisan, L Pham, S McIvor, SJ Russell, K-W Peng, Cancer Gene Ther. 2013 Sep, Pubmed Link
  • Fast Count-Regulated OSEM Reconstruction with Adaptive Resolution Recovery,  Vaissier, M. Goorden, A. Taylor, F. Beekman,, IEEE Trans. Med. Im., 2013 Aug. Pubmed Link.
  • Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies. S. Heskamp, O.C. Boerman, J.D. Molkenboer-Kuenen, W.J. Oyen, W.T. van der Graaf, H.W. van Laarhoven, Int J Cancer. 2013 Jul, Pubmed Link
  • 111In-cetuximab-F(ab’)2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts,K. van Dijk, B.A. Hoeben, H. Stegeman, J.H. Kaanders, G.M. Franssen, O.C. Boerman, J. Bussink, Radiother. Oncol 2013 Aug, Pubmed Link.
  • Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2RgnullMice,  Cany J, A.B. van der Waart, M. Tordoir, G.M. Franssen, B.N. Hangalapura, J. de Vries, O.C. Boerman, N. Schaap, R. van der Voort, J. Spanholtz, H. Dolstra, PLoS One 2013 Jun, Direct Link
  • Polyplex nanoparticles for cancer gene therapy, O. Durymanov, A.V. Ulasov, A.A. Rosenkranz, Y.V. Khramtsov, T.A. Slastnikova, I.V. Alekseenko, A.I. Kuzmich, O.A. Bezborodova, E.R. Nemtsova, R.I. Yakubovskaya, E.D. Sverdlov, A.S. Sobolev,Nanostructures: Phys & Tech. 2013 Jun. Direct Link
  • Modelling the physics in the iterative reconstruction for transmission computed tomography.  Nuyts, B. De Man, J.A. Fessler, W. Zbijewski, F.J. Beekman. Phys Med Biol. 2013 Jun. Pubmed Link
  • Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers, N. Kondo, T. Temma, Y. Shimizu, H. Watanabe, K. Higano, Y. Takagi, M. Ono, H. Saji, Cancer Science 2013 Apr, Pubmed Link
  • In Vivo Visualization and Quantification of (Disturbed) Oatp-Mediated Hepatic Uptake and Mrp2-Mediated Biliary Excretion of 99mTc-Mebrofenin in Mice,  Neyt, M.T. Huisman, C. Vanhove, H. De Man, M. Vliegen, L. Moerman, C. Dumolyn, G. Mannens, F. De Vos, J Nucl Med. 2013 Apr. Pubmed Link
  • Monitoring Tumor Response to Linifanib Therapy with SPECT/CT Using the Integrin αvβ3–Targeted Radiotracer 99mTc-3P-RGD2 Ji, Y. Zhou, M.J. Voorbach, G. Shao, Y. Zhang, G.B. Fox, D.H. Albert, Y. Luo, S. Liu, S.R. Mudd, J Pharmacol Exp Ther. 2013 Aug, Direct link
  • 99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging,  Ji, A. Czerwinski, Y. Zhou, G. Shao, F. Valenzuela, P. Sowiński, S. Chauhan, M. Pennington, S. Liu, Mol. Pharmaceutics 2013 Jul. Direct Link
  • Measles Virus Entry Through the Signaling Lymphocyte Activation Molecule Governs Efficacy of Mantle Cell Lymphoma Radiovirotherapy, Tanner S Miest, Marie Frenzke, Roberto Cattaneo, Mol Ther. 2013 Aug, Direct link
  • Development and characterization of [123I]-iodotiagabine for in vivo GABA-transporter imaging.  Schijns, M. van Kroonenburgh, F.J. Beekman, J. Verbeek, J. Herscheid, K. Rijkers, V. Visser-Vandewalle, G. Hoogland.,Nuc. Med. Communications, 2013 Feb. Pubmed Link
  • VECTor: A Pre-clinical Imaging System for Simultaneous Sub-mm SPECT-PET.M C. Goorden, F. van der Have, R. Kreuger, R.M. Ramakers, B. Vastenhouw, J.P.H. Burbach, J. Booij, F. J. Beekman.Nucl.Med., 2013 Feb. Pudmed Link
  • Monitoring Glioma Growth and Tumor Necrosis with the U-SPECT-II/CT Scanner by Targeting Integrin αvβ3, Shao G, Zhou Y, Wang F, Liu S. Mol Imaging 2013, Feb. Pubmed link
  • Performance evaluation of small-animal multipinhole μSPECT scanners, S.Deleye, R. Van Holen, J. Verhaeghe, S. Vandenberghe, S. Stroobants, S. Staelens, EJNMM  2013 Jan. Direct link
  • Effects of attenuation map accuracy on attenuation-corrected micro-SPECT images,  Wu, H.A. van Andel, P. Laverman, O.C. Boerman and F.J. Beekman, EJNMMI Research 2013. Direct link
  • Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer. Bult , S. G.C. Kroeze (equal contributor), M. Elschot, P.R. Seevinck, F.J. Beekman, H.W.A.M. de Jong, D.R.A. Uges, J.G.W. Kosterink, P.R. Luijten, W.E. Hennink, A.D. van het Schip, J.L.H.R. Bosch, J.F.W. Nijsen, J.J.M. Jans (equal contributor).PLoS ONE. 2013 Jan. Direct link
  • Differential loading methods for BMP-2 within injectable calcium phosphate cement. C. van de Watering, J.D.M. Molkenboer-Kuenen, O.C. Boerman, J.J.J.P. Beucken, J.A. Jansen, J.D. Molkenboer-Kuenen, J.J. van den Beucken. Journal Of Controlled Release. 2012 Dec. Direct link
  • Quantifying the effect of repetitive transcranial magnetic stimulation in the rat brain by μSPECT CBF scans, T, Wyckhuys, N. de Geeter, G. Crevecoeur, S. Stroobants, S. Staelens, Brain Stimulation, 2012 Oct.  Pubmed link
  • Quantitative Immuno-SPECT Monitoring Of Pretargeted Radioimmunotherapy With A Bispecific Antibody In An Intraperitoneal Nude Mouse Model Of Human Colon Cancer.  Schoffelen, W.T. van der Graaf, R.M. Sharkey, G.M. Franssen, W.J. McBride, Chien-Hsing Chang, D.L. Bos, D.M. Goldenberg, W.J. Oyen, O.C. Boerman.Journal Of Nuclear Medicine, 2012 Dec. Direct link
  • Radiolabeled Gelatin Type B Analogues Can Be Used For Non-Invasive Visualisation And Quantification Of Protein Coatings On 3D Porous Implants.  Kersemans, T. Desmet, C. Vanhove, P. Dubruel, F. Vos. Journal Of Materials Science: Materials In Medicine, 2012 Aug.Direct link
  • Multiplexed Eighty Channel PMT List-Mode Data Acquisition System for 27-511 keV Gamma Ray Imaging, Tapias, J. L. Villena, R. Kreuger, E. Lage, F.J. Beekman,IEEE Trans. Nucl. Sci., 2012 Jun. Direct Link
  • In Vitro And In Vivo Characterization Of Three 68Ga- And 111In-Labeled Peptides For Cholecystokinin Receptor Imaging.  Joosten, P. Laverman, O.C. Boerman, S. Roosenburg, A. Eek, F.P. Rutjes, F.L. van Delft. Molecular Imaging 2012 Sep. Direct link
  • Optimization of IGF-1R SPECT/CT Imaging Using 111In-Labeled F(ab’)(2) and Fab Fragments of the Monoclonal Antibody R1507. Heskamp, H.W.M. van Laarhoven, J.D.M. Molkenboer-Kuenen, W.H. Bouwman, W.T.A. van der Graaf, Wim J. G. Oyen, and Otto C. Boerman.Mol Pharm. 2012 Jul.  Pubmed link
  • Imaging of human epidermal growth factor receptor type 2 expression with 18F-labeled affibody molecule ZHER2:2395 in a mouse model for ovarian cancer.  Heskamp, P. Laverman, D. Rosik, F. Boschetti, W.T.A. van der Graaf, W.J.G. Oyen, H.W.M. van Laarhoven, V. Tolmachev and O.C. Boerman. J Nucl Med. 2012 Jan. Pubmed link
  • Monitoring Breast Tumor Lung Metastasis by U-SPECT-II/CT with an Integrin αvβ3-Targeted Radiotracer 99mTc-3P-RGD2. Zhou, G. Shao and S. Liu.Theranostics. 2012 Jun . Pubmed link
  • Evaluation of a technetium-99m labeled bombesin homodimer for GRPR imaging in prostate cancer.  Yu, G. Carlucci, H.J.K. Ananias, R.A.J.O. Dierckx, S. Liu, W. Helfrich, F. Wang, I.J. de Jong and P.H. Elsinga.Amino Acids. 2012 Jul. Pubmed link
  • 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography, computed tomography, and magnetic resonance imaging for the detection of experimental colorectal liver metastases. M. de Jong, T. Hendriks, R.P. Bleichrodt, H.M. Dekker, R.D. Mus, M. Gotthardt, E.P. Visser, W.j. Oyen and O.C. Boerman.Mol Imaging. 2012 Apr. Pubmed link
  • Multimerization improves targeting of peptide radiopharmaceuticals.  Carlucci, H.J.K. Ananias, Z. Yu, C. Van de Wiele, R.A. Dierckx, I.J. de Jong and P.H. Elsinga. Current Pharmaceutical Design 2012. Pubmed link
  • Radiolabelled peptides for oncological diagnosis. Laverman, J. K. Sosabowski, O.C. Boerman, W.J.G. Oyen. Eur J Nucl Med Mol Imaging. 2012 Feb. Pubmed link
  • Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-annexin A5 in a Colorectal Cancer Xenograft Model.  Vangestel ,C. van de Wiele, G. Mees, K. Mertens, S. Staelens, C. Reutelingsperger, P. Pauwels, M. van Damme, M. Peeters.Mol Imaging. 2012 Apr. Pubmed link
  • Fast Spiral SPECT with Stationary γ-Cameras and Focusing Pinholes. E.B. Vaissier, M.C. Goorden, B. Vastenhouw, F. van der Have, R. M. Ramakers, F.J. Beekman. J. Nucl Med. 2012 Aug. Direct link
  • 99mTechnetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7–14) as a Targeted Imaging Agent with MicroSPECT in a PC-3 Prostate Cancer Xenograft Model. J. Ananias, Z. Yu, R.A. Dierckx, C. van der Wiele, W. Helfrich, F. Wang, Y. Yan, X. Chen, IJ de Jong, P.H. Elsinga.Mol. Pharmaceutics, 2011 Aug. Pubmed link
  • Evaluation of the radiation dose in micro-CT with optimization of the scan protocol. Willekens , N. Buls, T. Lahoutte, L. Baeyens, C. Vanhove, V. Caveliers, R. Deklerck, A. Bossuyt, J. de Mey.Contrast Media Mol Imaging. 2010 Jul. Pubmed link
  • Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats.  Crunelle, T. Wit, K. Bruin, R. Ramakers, F. van der Have, F.J. Beekman, W. Brink, J. Booij.Nuclear Medicine and Biology. 2012 Jul. Direct link
  • Murine Cardiac Images Obtained With Focusing Pinhole SPECT Are Barely Influenced By Extra-Cardiac Activity”.  Branderhorst, F. van der Have, B. Vastenhouw, M. Viergever, F.J. Beekman. Physics In Medicine And Biology. 2012 Feb.  Direct link
  • Predicting IGF-1R Therapy Response in Bone Sarcomas: Immuno-SPECT Imaging with Radiolabeled R1507.D.G. Fleuren, Y.M.H. Versleijen-Jonkers, A.C.M. van de Luijtgaarden, J.D.M. Molkenboer-Kuenen, S. Heskamp, M.H.S. Roeffen, H.W.M. van Laarhoven, P.J. Houghton, W.J.G. Oyen, O.C. Boerman and W. T.A. van der Graaf,Clin Cancer Res. 2011 Dec. Direct link
  • Molecular SPECT Imaging: An Overview, M. Khalil,  J.L. Tremoleda, T.B. Bayomy, W. Gsell.  Int J Mol Imaging. 2011 Apr. Pubmed link
  • Imaging of Prostate Cancer with Immuno-PET and Immuno-SPECT Using a Radiolabeled Anti-EGP-1 Monoclonal Antibody.M. van Rij, R.M. Sharkey, D.M. Goldenberg, C. Frielink, J.D.M. Molkenboer, G.M. Franssen, W.M. van Weerden, W.J.G. Oyen, O.C. Boerman. J. Nucl Med. 2011 Oct. Direct link
  • 99mTc-(CO)3 His-Annexin A5 Micro-SPECT Demonstrates Increased Cell Death by Irinotecan During the Vascular Normalization Window Caused by Bevacizumab.  Vangestel, C. van de Wiele, N. Van Damme, S. Staelens, P. Pauwels, C.P.M. Reutelingsperger, M, Peeters,J. Nucl Med. 2011 Nov. Direct link
  • Quantitative multi-pinhole small-animal SPECT: uniform vs. non-uniform Chang attenuation correction. C Wu, J.R. de Jong, H A Gratama van Andel, F. van der Have, B Vastenhouw, P. Laverman, O.C. Boerman, R.A.J.O. Dierckx,  F.J. Beekman. Phys Med Biol. 2011 Sep. Direct link
  • Image quality phantom and parameters for high spatial resolution small-animal SPECT.P. Visser, A.A. Harteveld, A.P.W. Meeuwis, J.A. Disselhorst, F.J. Beekman, W.J.G. Oyen, O.C. Boerman. Nucl. Instr. and Meth 2011 Oct. Direct link
  • Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat.Wyckhuys S. Staelens, B. Van Nieuwenhuyse, S. Deleye, H. Hallez, K. Vonck, R. Raedt, W. Wadman, P. Boon, NeuroImage. Pubmed Link
  • Absolute quantitative total-body small-animal SPECT with focusing pinholes.  Wu, F. van der Have, B. Vastenhouw, R.A. Dierckx, A.M. Paans, F.J. Beekman,EJNM & Mol. Im. Pubmed link
  • Measurement of porto-systemic shunting in mice by novel three-dimensionalmicro-single photon emission computed tomography imaging enabling longitudinal follow-up,  van Steenkiste, S. Staelens, S. Deleye, F. De Vos, S. Vandenberghe, A. Geerts, C. Van de Wiele, M. De Vos, H. Van Vlierberghe, I. Colle,LiverInt. Pubmed link
  • Accurate coregistration between Ultra-High-Resolution micro-SPECT and circular Cone-beam micro-CT scanners, Ji, F. van der Have, H. Gratama van Andel, R.M. Ramakers, F.J. Beekman, Int. J. Biomed. Imaging. Pubmed link
  • Radiolabeled cetuximab Dose optimization for EGFR imaging in a head-and-neck squamous cell carcinoma model, A. Hoeben, J.D. Molkenboer-Kuenen, W.J. Oyen, W.J. Peeters, J.H. Kaanders, J. Bussink, O.C. Boerman, Int. J. Cancer. Pubmed link
  • Targeted multi-pinhole SPECT.  Branderhorst, B. Vastenhouw, F. van der Have, E. Blezer, W. Bleeker, F.J. Beekman. Eur J Nucl Med Mol Imaging. Direct link
  • Pixel-based subsets for rapid multi-pinhole SPECT reconstruction. W. Branderhorst, B. Vastenhouw, F.J. Beekman, Phys Med Biol. Direct link
  • ImmunoSPECT and ImmunoPET in IGF-1R Expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model, S. Heskamp, H.W. van Laarhoven, J.D. Molkenboer-Kuenen, G.M. Franssen, Y.M. Versleijen-Jonkers, W.J. Oyen, W.T. van der Graaf, O.C. Boerman, Nucl. Med. Pubmed link
  • High-resolution tomography of positron emitters with clustered pinhole SPECT, C. Goorden, F.J. Beekman, Phys. Med Biol. Pubmed link
  • Small-animal SPECT and SPECT/CT application in cardiovascular research.  Golestani, C. Wu, R.A. Tio, C.J. Zeebregts, A.D. Petrov, F.J. Beekman, R.A. Dierckx, H.H. Boersma, R.H. Slart,Eur J Nucl Med Mol. Im. Pubmed link
  • In vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter,  De Bruyne, L. Wyffels, T.L. Boos, S. Staelens, S. Deleye, K.C. Rice, F. De Vos, Nucl. Med. Bio. Pubmed link
  • In vitro and in vivo evaluation of 99mTc-labeled tricarbonyl His-annexin A5 as an imaging agent for the detection of phosphatidylserine-expressing cells.  Vangestel, M. Peeters, R. Oltenfreiter, Y. D’Asseler, S. Staelens, M. Van Steenkiste, J. Philippé, D. Kusters, C. Reutelingsperger, N. Van Damme, C. Van de Wiele,Nucl. Med. Biol. Pubmed Link
  • Theoretical analysis of full-ring multi-pinhole brain SPECT. C. Goorden, M.C. Rentmeester, F.J. Beekman,. Phys. Med. Biol. Pubmed link
  • U-SPECT-II: An Ultra-High-Resolution Device For Molecular Small-Animal Imaging. F.van der Have, B. Vastenhouw, R.M. Ramakers, W. Branderhorst, J.O. Krah, C. Ji, S.G. Staelens, F.J. Beekman. Journal Of Nuclear Medicine. Direct link
  • Preclinical evaluation of monoclonal antibody 14C5 for the imaging of pancreatic cancer: in vitro and in vivo comparison of 125I-, 111In-DTPA- and 111In-DOTA-14C5,  Vervoort, I. Burvenich, S. Staelens, C. Dumolyn, E. Waegemans, M. Van Steenkiste, S.K. Baird, A.M. Scott, F. De Vos, Cancer Biother Radiopharm.Pubmed link
  • Recent advances in small-animal cardiovascular imaging, M. Tsui, D.L. Kraitchman, J Nucl Med. Pubmed link
  • 3-D Rat brain phantom for high resolution molecular imaging. Beekman et al.  of the IEEE. Direct link
  • Effect of cyclosporin A administration on the biodistribution and multipinhole muSPECT imaging of [123I]R91150 in rodent brain. Blanckaert, I. Burvenich, S. Staelens, S. De Bruyne, L. Moerman, L. Wyffels, F. De Vos, Eur J Nucl Med Mol ImagingPubmed link
  • Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT.  Vastenhouw, F. van der Have, A.J. van der Linden, L. von Oerthel, J. Booij, J.P. Burbach, M.P. Smidt, F.J. Beekman, Mol Psychiatry.Pubmed link
  • System calibration and statistical image reconstruction for ultra-high resolution stationary pinhole SPECT,  van der Have , B. Vastenhouw, M. Rentmeester, F.J. Beekman, IEEE Trans Med Imaging. Pubmed link
  • Optimizing multi-pinhole SPECT geometries using an analytical model.  Rentmeester, F. van der Have, F. Beekman,Phys Med Biol. 2007 May. Pubmed Link
  • The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging. J. Beekman, F. van der Have, Eur J Nucl Med & Mol Im.Pubmed link
  • Multi-modality imaging on track,J.Beekman, B.F. Hutton, Eur J Nucl Med Mol Imaging.Pubmed link
  • U-SPECT-I: A Novel System for Submillimeter-Resolution Tomography with Radiolabeled Molecules in Mice, F.J. Beekman, F. van der Have, B. Vastenhouw, A.J. van der Linden, P.P van Rijk, J.P. Burbach, M.P. Smidt. J Nucl Med. Pubmed link

 

 

Selected journal papers

Exiting applications of MILabs imaging equipment.

Ultra-Small Biocompatible Bi2Se3 Nanodots for Multimodal-Imaging-Guided Synergistic Radio-Photothermal Therapy against Cancer. F. Mao, L. Wen, C. Sun, S. Zhang, G. Wang, J. Zeng, Y. Wang, J. Ma, M. Gao, Z. Li. ACS Nano 2016 Nov. Direct Link
99mTc-Duramycin SPECT imaging of early tumor response to targeted therapy: a comparison with 18F-FDG PET. F. Elvas, J. Boddaert, C. Vangeste, K. Pak, B. Gray, S. Kumar-Singh, S. Staelens, S. Stroobants, L. Wyffels. J. Nucl. Med. 2016 Nov. Pubmed Link
Novel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) as potential radiotracers for heart imaging. M. Liu, Y. Zheng, U. Avcibasi, S. Liu. Nuclear Medicine and Biology 2016 Nov. Pubmed Link
Comparison of biological properties of 99mTc-labeled cyclic RGD Peptide trimer and dimer useful as SPECT radiotracers for tumor imaging. Z. Zhao, Y. Yang, W. Fang, S. Liu. Nucl. Med Biol. 2016 Nov. Pubmed Link
Novel 99mTc(III) Complexes [99mTcCl(CDO)(CDOH)2B-R] (CDOH2 = Cyclohexanedione Dioxime) Useful as Radiotracers for Heart Imaging. M. Liu, W. Fang, S. Liu,  Bioconjugate Chem. 2016 Oct. Pubmed Link
68Ga/177Lu-NeoBOMB1, A Novel Radiolabeled GRPR Antagonist For Theranostic Use In Oncology. S.U. Dalm, I.L. Bakker, E. de Blois, G.N. Doeswijk, M.W. Konijnenberg, F. Orlandi, D. Barbato, M. Tedesco, T. Maina, B.A. Nock, M. de Jong. J Nucl Med. 2016 Sep. PubMed Link
Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy. Y. Chao, G. Wang, C. Liang, X. Yi, X. Zhong, J. Liu, M. Gao, K. Yang, L. Cheng. Small 2016 Aug. Pubmed Link
Ambient Aqueous Synthesis of Ultra-small PEGylated Cu2−xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer. S. Zhang, C. Sun, J. Zeng, Q. Sun, G. Wang, Y. Wang, Y. Wu, S. Dou, M. Gao, and Z. Li. Advanced materials 2016 Aug. Pubmed Link
Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity. C. Vangestel, D. Thomae, J. Van Soom, J. Ides, L. wyffels, P. Pauwels, S. Stroobants, P. Van der Veken, V. Magdolen, J. Joossens, K. Augustyns, S. Staelens. Contrast Media Mol Imaging 2016 Aug. Pubmed Link
Improved quantification of the beta cell mass after pancreas visualization with 99mTc-demobesin-4 and beta cell imaging with 111In-exendin-3 in rodents. I. van der Kroon, L. Joosten, B.A. Nock, T. Maina, O.C. Boerman, M. Brom, M. Gotthardt. Mol. Pharm 2016 Aug. Pubmed Link
In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage mediated clearance from the bone marrow.  L.T. van der Meer, S.Y.A. Terry, D. van Ingen Schenau, K.C. Andree, G.M. Franssen, D.M. Roeleveld, B.M. Metselaar, T. Reinheckel, P.M. Hoogerbrugge, O.C. Boerman, F.N. van Leeuwen. J Nucl Med. 2016 Aug. Pubmed Link
Liposomal treatment of experimental arthritis can be monitored non-invasively with radiolabeled anti-FAP antibodies. T. van der Geest, P. Laverman, D. Gerrits, B. Walgreen, M.H. Helsen, C. Klein, T.K. Nayak, G. Storm, J.M. Metselaar, M.I. Koenders, O.C. Boerman. J Nucl Med. 2016 Aug. Pubmed Link
Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function. S. Neyt, M. Vliegen, B. Verreet, S. De Lombaerde, K. Braeckman, C. Vanhove, M.T. Huisman, C. Dumolyn, K. Kersemans, F. Hulpia, S. Van Calenbergh, G. Mannens, F. De Vos. Nucl Med Biol. 2016 Jul. Pubmed Link
Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers. L. Wen, L. Chen, S. Zheng, J. Zeng, G. Duan, Y. Wang, G. Wang, Z. Chai, Z. Li, M. Gao. Advanced materials 2016 Aug. Pubmed Link
Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging. M.A. Stammes, V.T. Knol-Blankevoort, L.J. Cruz, H.R.I.J. Feitsma, L. Mezzanotte, R.A. Cordfunke, R. Sinisi, E.A. Dubikovskaya, A. Maeda, R.S. DaCosta, K. Bierau, A. Chan, E.L. Kaijzel, T.J.A. Snoeks, E.R. van Beek, C.W.G.M. Löwik. Mol. Imaging Biol. 2016 Jun. Pubmed Link
In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT. L. Jennings, O. Ivashchenko, I.J. Marsman, A.C. Laan, A.G. Denkova, G. Waton, F.J. Beekman, F. Schosseler, E. Mendes. Biomater Sci. 2016 Jun. Pubmed Link
High-resolution clustered-pinhole 131Iodine SPECT imaging in mice. F. van der Have, O. Ivashchenko, M.C. Goorden, R.M. Ramakers, F.J. Beekman. Nuclear Medicine and Biology. 2016 Jun. Pubmed Link
Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent. K.L.S. Chatalic, S. Heskamp, M. Konijnenberg, J. Molkenboer-Kuenen, G.M. Franssen, M.C. Clahsen-van Groningen, M, Schottelius, H. Wester, W.M. van Weerden, O.C. Boerman, M. de Jong. Theranostics. 2016 Jun. Pubmed Link
Similarity-regulation of OS-EM for accelerated SPECT reconstruction. P.E. Vaissier, F.J. Beekman, M.C. Goorden. Phys Med Biol. 2016 Jun. Pubmed Link
Comparison of LDPI to SPECT perfusion imaging using (99m)Tc-sestamibi and (99m)Tc-pyrophosphate in a murine ischemic hind limb model of neovascularization. G. Hendrikx, M.H. Vries, M. Bauwens, M. De Saint-Hubert, A. Wagenaar, J. Guillaume, L. Boonen, M.J. Post, F.M. Mottaghy. EJNMMI Res.  2016 May. Pubmed Link
Radiolabeled cyclic RGD peptides as radiotracers for tumor imaging. J. Shi, F. Wang, S. Liu. Biophys Rep. 2016 Apr. PubMed Link
SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments. W.A. Eter, S. Parween, L. Joosten, C. Frielink, M. Eriksson, M. Brom, U. Ahlgren,  M. Gotthardt. Sci Rep. 2016 Apr. Pubmed Link
Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography. J. Lalut, B.B. Tournier, T. Cailly, C. Lecoutey, S. Corvaisier, A. Davis, C. Ballandonne, M. Since, P. Millet, F. Fabis, P. Dallemagne, C. Rochais. Eur J Med Chem. 2016 Mar. Pubmed Link
Optimizing modelling in iterative image reconstruction for preclinical pinhole PET, M.C. Goorden, J. van Roosmalen, F. van der Have, F.J. Beekman. Physics in medicine and biology 2016  Apr. Pubmed Link
   
Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. K. Kanazaki, K. Sano, A. Makino, F. Yamauchi, A. Takahashi , T. Homma, M. Ono, H. Saji. J Control Release. 2016 Feb. Pubmed Link
SPECT/CT imaging of Pluronic nanocarriers with varying PEO block length and aggregation state. A. Arranja, O. Ivashchenko, A. Denkova, K. Morawska, S. van Vlierberghe, P. Dubruel, G. Waton, F. Beekman, F. Schosseler, E. Mendes. Mol Pharm. 2016 Feb, Pubmed Link
Early prediction of tumor response to treatment: pre-clinical validation of 99mTc-duramycin. F. Elvas, C. Vangestel, K.Y. Pak, P. Vermeulen, B. Gray, S. Stroobants, S. Staelens, L. Wyffels. J Nucl Med. 2016 Feb. Pubmed Link
Noninvasive imaging of islet transplants with 111In-exendin-3. I. van der Kroon I, K. Andralojc, S.M. Willekens, D. Bos, L. Joosten, O. Boerman, M. Brom, M. Gotthardt. J Nucl Med. 2016 Jan. Pubmed Link
Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia. W. Shen, M.M. Patnaik, A. Ruiz, S.J. Russell, K.W. Peng. Blood. 2015 Dec. Pubmed Link
Monitoring therapy response of experimental arthritis with radiolabeled tracers targeting fibroblasts, macrophages or integrin αvβ3. S.Y. Terry, M. Koenders, G. Franssen, T. Nayak, A. Freimoser-Grundschober, C. Klein, W. Oyen, O. Boerman, P. Laverman. J Nucl Med. 2015 Dec. Pubmed Link
Utilizing high-energy gamma photons for high-resolution 213Bi SPECT in mice. J. de Swart, H.S. Chan, M.C. Goorden, A. Morgenstern, F. Bruchertseifer, F.J. Beekman, M. de Jong, M. Konijnenberg. J Nucl Med. 2015 Dec. Pubmed Link
SPECT of transplanted islets of Langerhans by dopamine 2 receptor targeting in a rat model. S.M. Willekens, I. van der Kroon, L. Joosten, C.  Frielin, O.C. Boerman, S.A. van den Broek, M. Brom, M. Gotthardt. Mol Pharm. 2015 Nov. Pubmed Link
 Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer. Xiaoyan Zhong, Kai Yang, Zhiliang Dong, Xuan Yi, Yong Wang, Cuicui Ge, Yuliang Zhao, Zhuang Liu, Advanced Functional Materials, 2015 Nov. Direct Link
Central delivery of iodine-125–labeled cetuximab, etanercept and anakinra after perispinal injection in rats: possible implications for treating Alzheimer’s disease. M.E. Roerink, R.J.M. Groen, G. Franssen, B. Lemmers-van de Weem, O.C. Boerman, J.W.M. van der Meer. Alzheimer’s Research and Therapy. 2015 Nov. Direct Link
Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin. W.A. Eter, D. Bos, C. Frielink, O.C. Boerman, M. Brom, M. Gotthardt. Sci Rep. 2015 Oct. Direct Link
5-HT2A receptor SPECT imaging with [123I]R91150 under P-gp inhibition with tariquidar: More is better? S. Tsartsalis, B.B. Tournier, T. Huynh-Gatz, N. Dumas, N. Ginovart, M. Moulin-Sallanon, P. Millet. Nucl Med Biol. 2015 Sept. Pubmed Link
Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers. N. Kondo, T. Temma, Y. Shimizu, M. Ono, H. Saji. Biol. Pharm. Bull. 2015 Sept. Pubmed Link
Biodistribution of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing. S.A. Low, C.V. Galliford, J. Yang, P.S. Low, and J. Kopecek. Biomacromolecules 2015 Sept. Pubmed Link
Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake. M. Rotman, M.M. Welling, M.L. van den Boogaard, L.G. Moursel, L.M. van der Graaf, M.A. van Buchem, S.M. van der Maarel, L. van der Weerd. Nucl Med Biol. 2015 Aug. Pubmed Link
Oncolytic measles virus as a novel therapy for malignant peripheral nerve sheath tumors. D.R. Deyle, D.Z. Escobar, K.W. Peng, D. Babovic-Vuksanovic. Gene. 2015 Jul. Pubmed Link
111In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages. S.Y. Terry, O.C. Boerman, D. Gerrits, G.M. Franssen, J.M. Metselaar, S. Lehmann, W.J. Oyen, C.A. Gerdes, K. Abiraj. EJNMMol Imaging. 2015 May. Pubmed Link
Non-invasive imaging of tumor PD-L1 expression using radiolabeled anti-PD-L1 antibodies. S. Heskamp, W. Hobo, J.D. Molkenboer-Kuenen, D. Olive, W.J. Oyen, H. Dolstra, O.C. Boerman. Cancer Res. 2015 May. Pubmed Link
Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET. K. Miwa, M. Inubushi, Y. Takeuchi, T. Katafuchi, M. Koizumi, T. Saga, M. SasakiAnn Nucl Med. 2015 Apr, Direct Link
Characterization of [(99m)Tc]Duramycin as a SPECT Imaging Agent for Early Assessment of Tumor Apoptosis. F. Elvas,  C. Vangestel, S. Rapic, J. Verhaeghe, B. Gray, K. Pak, S. Stroobants, S. Staelens, L. Wyffels. Mol Imaging Biol. 2015 Apr, Pubmed Link
ImmunoPET and immunoSPECT of rheumatoid arthritis with radiolabeled anti-fibroblast activation protein (FAP) antibody correlates with severity of arthritis. P. Laverman, T. van der Geest, S.Y. Terry, D. Gerrits, B. Walgreen, M.M. Helsen, T.K. Nayak, A. Freimoser-Grundschober, I. Waldhauer, R.J. Hosse, E. Moessner, P. Umana, C. Klein, W.J. Oyen, M.I. Koenders, O.C. Boerman. J Nucl Med. 2015 Apr, Pubmed Link
Development of a hybrid tracer for SPECT & optical imaging of bacterial infections. M. Welling, A. Bunschoten, J. Kuil, R. Nelissen, F.J. Beekman, T. Buckle, F.W. van Leeuwen. Bioconjug Chem. 2015 Apr, Pubmed Link
A Standardized Method for the Construction of Tracer Specific PET and SPECT Rat Brain Templates: Validation and Implementation of a Toolbox. D. Vállez Garcia, C. Casteels, A.J. Schwarz, R.A. Dierckx, M. Koole, J. Doorduin. PLoS One. 2015 Mar, Pubmed Link
uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery. M.C. Boonstra, P.B. van Driel, D.M. van Willigen, M.A. Stammes, H.A. Prevoo, Q.R. Tummers, A.P. Mazar, F.J. Beekman, R.J. Kuppen, C.J. van de Velde, C.W. Löwik, J.V. Frangioni, F.W. van Leeuwen, C.F. Sier, A.L. Vahrmeijer. Oncotarget. 2015 Mar, Pubmed Link
SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model. S. Tsartsalis, N. Dumas, B.B. Tournier, T. Pham, M. Moulin-Sallanon, M. Grégoire, Y. Charnay, P. Millet. EJNMMI Research. 2015 Mar, Pubmed Link
99m Tc Radiolabeling and Biological Evaluation of Nanoparticles Functionalized with a Versatile Coating Ligand. M. Felber, M. Bauwens, J.M. Mateos, S. Imstepf, F.M. Mottaghy, R. Alberto. Chemistry. 2015 Mar, Pubmed Link
Design of a serotonin 4 receptor radiotracer with decreased lipophilicity for single photon emission computed tomography. N. Fresneau, N. Dumas, B.B. Tournier, C. Fossey, C. Ballandonne, A. Lesnard, P. Millet, Y. Charnay, T. Cailly, J. Bouillon, F. Fabis. Eur J Med Chem. 2015 Mar, Pubmed Link
Radionuclide and fluorescence imaging of clear cell renal cell carcinoma using dual-labeled anti-Carbonic Anhydrase IX antibody G250. C.H. Muselaers, M. Rijpkema, D.L. Bos, J.F. Langenhuijsen, W.J. Oyen, P.F. Mulders, E. Oosterwijk, O.C. Boerman. J Urol 2015 Feb, Pubmed Link
111In-cetuximab-F(ab’)2 SPECT and 18F-FDG PET for prediction and response monitoring of combined-modality treatment of human head and neck carcinomas in a mouse model. L.K. van Dijk, O.C. Boerman, G.M. Franssen, J.H.a.M. Kaanders, J. Bussink. J Nucl Med. 2015 Feb, Pubmed Link
Ultra-high-sensitivity sub-mm mouse SPECT. O. Ivashchenko, F. van der Have, M.C. Goorden, R.M. Ramakers, F.J. Beekman. J Nucl Med. 2015 Feb, Pubmed Link
Molecular imaging of angiogenesis after myocardial infarction by (111)In-DTPA-cNGR and (99m)Tc-sestamibi dual-isotope myocardial SPECT. G. Hendrikx, M. De Saint-Hubert, I. Dijkgraaf, M. Bauwens, K. Douma, R. Wierts, I. Pooters, N.M. Van den Akker, T.M. Hackeng, M.J. Post, F.M. Mottaghy. EJNMMI Res. 2015 Jan  Pubmed Link
Evaluation of a nonpeptidic ligand for imaging of cholecystokinin 2 receptor-expressing cancers. C. Wayua and P.S. Low. J Nucl Med. 2015 Jan, Pubmed Link
Impact of Boronate Capping Groups on Biological Characteristics of Novel 99mTc(III) Complexes [99mTcCl(CDO)(CDOH)2B-R]. S. Liu, Y. Zheng, Y. Yang, E. Tomaselli, W. Fang. J. Bioconjug Chem. 2015 Jan, Pubmed Link
Drug composition matters: the influence of carrier concentration on the radiochemical purity, hydroxyapatite affinity and in-vivo bone accumulation of the therapeutic radiopharmaceutical 188Rhenium-HEDP. R. Lange, J.M. de Klerk, H.J. Bloemendal, R.M. Ramakers, F.J. Beekman, M.M. van der Westerlaken, N.H. Hendrikse, R. Ter Heine. Nucl Med Biol. 2015 Jan, Pubmed Link
Cetuximab-F(ab’)2-SPECT and FDG-PET for prediction and response monitoring of combined modality treatment of human head and neck carcinomas in a mouse model. L.K. van Dijk, O.C. Boerman, G.M. Franssen, J.H. Kaanders, J. Bussink. J Nucl Med. 2014 Dec. Pubmed Link
Noninvasive 3D imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene. R.D. Hickey, S.A. Mao, B. Amiot, L. Suksanpaisan, A. Miller, R. Nace, J. Glorioso, M.K. O’Connor, K.W. Peng, Y. Ikeda, S.J. Russell, S.L. Nyberg, Liver Transpl. 2014 Dec, Pubmed Link
Early Response Monitoring with 18F-FDG PET and Cetuximab-F(ab’)2-SPECT After Radiotherapy of Human Head and Neck Squamous Cell Carcinomas in a Mouse Model. L.K. van Dijk, O.C. Boerman, G.M. Franssen, J. Lok, J.H. Kaanders, J. Bussink, J Nucl Med. 2014 Oct, Pubmed Link
Folate Receptor-β Imaging Using 99mTc-Folate to Explore Distribution of Polarized Macrophage Populations in Human Atherosclerotic Plaque. N.A. Jager, J. Westra, R. Golestani, G.M. van Dam, P.S. Low, R.A. Tio, R.H.J.A. Slart, H.H. Boersma, M. Bijl, C.J. Zeebregts, J Nucl Med. 2014 Oct, Direct Link
Can 111In-RGD2 Monitor Response to Therapy in Head and Neck Tumor Xenografts? S.Y. Terry, K. Abiraj, J. Lok, D. Gerrits, G.M. Franssen, W.J. Oyen, O.C. Boerman, J Nucl Med. 2014 Oct, Pubmed Link
U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform. M.N. van Oosterom, R. Kreuger, T. Buckle, W. A. Mahn, A. Bunschoten, L. Josephson, F.W.B. van Leeuwen, F.J. Beekman, EJNMMI Research 2014 Oct, Pubmed Link
Combination of Single-Photon Emission Computed Tomography and Magnetic Resonance Imaging to Track 111In-Oxine-Labeled Human Mesenchymal Stem Cells in Neuroblastoma-Bearing Mice. L. Cusso, I. Mirones, S. Pena-Zalbidea, V. Garcia-Vazquez, J. Garcia-Castro, M. Desco, Mol. Imaging. 2014 Sept, Pubmed Link
Pretargeted dual-modality immuno-SPECT and near-infrared fluorescence imaging for image-guided surgery of prostate cancer. S. Lütje, M. Rijpkema, D.M. Goldenberg, C.M. van Rij, R.M. Sharkey, W.J. McBride, G.M. Franssen, C. Frielink, W. Helfrich, W.J. Oyen, O.C. Boerman, Cancer Res. 2014 Sept, Pubmed Link
Quarter-mm resolution molecular mouse imaging with U-SPECT+, O. Ivashchenko, F. van der Have, J.L. Villena, H.C. Groen, R.M. Ramakers, H.H. Weinans, F.J. Beekman, Molecular Imaging 2014 Sept, Pubmed Link
In vivo and in vitro evidence that 99mTc-HYNIC-interleukin-2 is able to detect T lymphocytes in vulnerable atherosclerotic plaques of the carotid artery. A.W. Glaudemans, E. Bonanno, F. Galli, C.J. Zeebregts, E.F. de Vries, M. Koole, G. Luurtsema, H.H. Boersma, M. Taurino, R.H. Slart, A. Signore. Eur J Nucl Med Mol Imaging. 2014 Sept, Pubmed Link
Influence of Respiratory Gating, Image Filtering and Animal Positioning on High-Resolution ECG-Gated Murine Cardiac SPECT, C. Wu, P.E.B. Vaissier, B. Vastenhouw, J.R. de Jong, R.H.J.A. Slart, F.J. Beekman, Molecular Imaging 2014 Sept, Pubmed Link
Impact of Multiple Negative Charges on Blood Clearance and Biodistribution Characteristics of 99mTc-Labeled Dimeric Cyclic RGD Peptides. Y. Yang, S. Ji, S. Liu, Bioconjug Chem. 2014 Aug. Pubmed Link
Development of kit formulations for 99m TcN-MPO: a cationic radiotracer for myocardial perfusion imaging. Y. Zheng, S. Ji, E. Tomaselli, S. Liu, J Labelled Comp Radiopharm 2014 July. Pubmed Link
SPECT- and Fluorescence Image-Guided Surgery Using a Dual-Labeled Carcinoembryonic Antigen-Targeting Antibody, M. Rijpkema, W.J. Oyen, D. Bos, G.M. Franssen, D.M. Goldenberg, O.C. Boerman, J Nucl Med 2014 July. Pubmed Link
Performance Assessment of a Preclinical PET Scanner with Pinhole Collimation by Comparison to a Coincidence-Based Small-Animal PET Scanner, M.D. Walker, M.C. Goorden, K. Dinelle, R.M. Ramakers, S. Blinder, M. Shirmohammad, F. van der Have, F.J. Beekman, V. Sossi, J Nucl Med 2014 Aug. Direct Link
Optimizing Lutetium 177–Anti–Carbonic Anhydrase IX Radioimmunotherapy in an Intraperitoneal Clear Cell Renal Cell Carcinoma Xenograft Model, C.H.J. Muselaers, E. Oosterwijk, D.L. Bos, W.J.G. Oyen, P.F.A. Mulders, O.C. Boerman, Mol Imaging, 2014 June. Pubmed Link
Oncolytic vaccinia virotherapy for endometrial cancer, Y.P. Liu, J. Wang, V.A. Avanzato, J.N. Bakkum-Gamez, S.J. Russell, J.C. Bell, K.W. Peng, Gynecol Oncol. 2014 March. Direct Link
Optical Imaging of Renal Cell Carcinoma with Anti-Carbonic Anhydrase IX Monoclonal Antibody Girentuximab, C.H. Muselaers, A.B. Stillebroer, M. Rijpkema, G.M. Franssen, E. Oosterwijk, P.F. Mulders, W.J. Oyen, O.C. Boerman, J Nucl Med. 2014 April. Pubmed Link
In vivo molecular imaging of apoptosisand necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging, M. De Saint-Hubert, M. Bauwens, N. Deckers, M. Drummen, K. Douma, P. Granton, G. Hendrikx, D. Kusters, J. Bucerius, C.P. Reutelingsperger, F.M. Mottaghy, Mol Imaging Biol. 2014 April. Pubmed Link
Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody, S. Lütje, M. Rijpkema, G.M. Franssen, G. Fracasso, W. Helfrich, A. Eek, W.J.Oyen, M. Colombatti, O.C. Boerman, J Nucl Med. 2014 April. Pubmed Link
Assessing Cardiac Injury in Mice With Dual Energy-MicroCT, 4D-MicroCT, and MicroSPECT Imaging After Partial Heart Irradiation, C.L. Lee, H. Min, N. Befera, D. Clark, Y. Qi, S. Das, G.A. Johnson, C.T. Badea, D.G. Kirsch, Int J Radiat Oncol Biol Phys. 2014 Mar. Pubmed Link
Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent, J.R. Ashton, N. Befera, D. Clark, Y. Qi, L. Mao, H.A. Rockman, G.A. Johnson, C.T. Badea, Contrast Media Mol Imaging. 2014 Mar. Pubmed Link
Dynamics of IGF-1R Expression During Endocrine Breast Cancer Treatment, S. Heskamp, O.C. Boerman, J.D. Molkenboer-Kuenen, R.H. Koornstra, S.C. Linn, W.J. Oyen, W.T. van der Graaf, H.W. van Laarhoven, Mol Imaging Biol. 2014 Feb 15. Pubmed Link
Imaging Integrin αvβ3 on Blood Vessels with 111In-RGD2 in Head and Neck Tumor Xenografts, S.Y. Terry, K. Abiraj, C. Frielink, L.K. van Dijk, J. Bussink, W.J. Oyen, O.C. Boerman, J Nucl Med. 2014 Feb. Pubmed Link
The role of preclinical SPECT in oncological and neurological research in combination with either CTor MRI, M.R. Bernsen, P.E.B. Vaissier, R. van Holen, J. Booij, F.J. Beekman, M. de Jong. Eur J Nucl Med Mol Imaging, April 2014. Direct Link
OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain, T. Kikuchi, T. Okamura, H. Wakizaka, M. Okada, K. Odaka, J. Yui, A.B. Tsuji, T. Fukumura, M.R. Zhang, J Cereb Blood Flow Metab. 2014 Feb 5, Pubmed Link
Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases. R. ter Heine, R. Lange, O. B Breukels, H. J. Bloemendal, R. G Rummenie, A. M Wakker, H. de Graaf, F. J Beekman, M.  van der Westerlaken, M. M. Malingré, J.P.M. Wielders, L. van den Berge,  H. Hendrikse, J.M.H. de Klerk, Int. J. Pharmaceutics 2014, Pubmed Link
3D histological validation of high-resolution SPECT of antibody distributions within xenografts. W. Branderhorst, E.L.A. Blezer, M. Houtkamp, R.M. Ramakers, J. H. van den Brakel, H. Witteveen, F. van der Have, H. A. Gratama van Andel, B. Vastenhouw, M. Stigter-van Walsum, G.A.M.S. van Dongen, M. A. Viergever, W.K. Bleeker, F.J. Beekman. J. Nucl. Med. 2014, Direct Link
Small-Animal Single-Photon Emission Computed Tomographic Imaging of the Brain Serotoninergic Systems in Wild-Type and Mdr1a Knockout Rats, N. Dumas, M. Moulin-Sallanon, N. Ginovart, B.B. Tournier, P. Suzanne, T. Cailly, F. Fabis, S. Rault, Y. Charnay, P. Millet, Molecular Imaging, 2014 Febr, Pubmed link.
SPECT vs. PET monitoring of bone defect healing and biomaterial performance in vivo, M. Ventura, G.M. Franssen, E. Oosterwijk, O.C. Boerman, J.A. Jansen, X.F. Walboomers, J Tissue Eng Regen Med. 2014 Jan, Pubmed link
Imaging of Epidermal Growth Factor Receptor Expression in Head and Neck Cancer with SPECT/CT and 111In-Labeled Cetuximab-F(ab9)2L.K. van Dijk, B.A.W. Hoeben, J.H.A.M. Kaanders, G.M. Franssen, O.C. Boerman, J. Bussink. J Nucl Med 2013 Oct, Pubmed Link
Microdistribution of MC1R-targeted polyplexes in murine melanoma tumor tissue, M.O. Durymanova, T.A. Slastnikovaa, A.I. Kuzmichd, Y.V. Khramtsova, A.V. Ulasova, A.A. Rosenkranza, S.Y. Egorovf, E.D. Sverdlovc, A.S. Sobolev, Biomaterials. 2013 Oct, Direct Link
Comparison of 4D-MicroSPECT and MicroCT for Murine Cardiac Function, N.T. Befera, C.T. Badea, G.A. Johnson, Mol. Imaging Biol. 2013 Sep, Direct Link
The strength of small: Improved targeting of Insulin-like Growth Factor-1 Receptor (IGF-1R) with F(ab’)2-R1507 fragments in Ewing sarcomas, E.D. Fleuren, Y.M. Versleijen-Jonkers, S. Heskamp, M.H. Roeffen, W.H. Bouwman, J.D. Molkenboer-Kuenen, H.W. van Laarhoven, W.J. Oyen, O.C. Boerman, W.T. van der Graaf. Eur J Cancer, 2013 Sep. Pubmed Link
Oral contrast enhances the resolution of in-life NIS reporter gene imaging, L Suksanpaisan, L Pham, S McIvor, SJ Russell, K-W Peng, Cancer Gene Ther. 2013 Sep, Pubmed Link
Fast Count-Regulated OSEM Reconstruction with Adaptive Resolution Recovery, P. Vaissier, M. Goorden, A. Taylor, F. Beekman,, IEEE Trans. Med. Im., 2013 Aug. Pubmed Link.
Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies. S. Heskamp, O.C. Boerman, J.D. Molkenboer-Kuenen, W.J. Oyen, W.T. van der Graaf, H.W. van Laarhoven, Int J Cancer. 2013 Jul, Pubmed Link
111In-cetuximab-F(ab’)2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts, L.K. van Dijk, B.A. Hoeben, H. Stegeman, J.H. Kaanders, G.M. Franssen, O.C. Boerman, J. Bussink, Radiother. Oncol 2013 Aug, Pubmed Link.
Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rgnull Mice, J. Cany J, A.B. van der Waart, M. Tordoir, G.M. Franssen, B.N. Hangalapura, J. de Vries, O.C. Boerman, N. Schaap, R. van der Voort, J. Spanholtz, H. Dolstra, PLoS One 2013 Jun, Direct Link
Polyplex nanoparticles for cancer gene therapy, M.O. Durymanov, A.V. Ulasov, A.A. Rosenkranz, Y.V. Khramtsov, T.A. Slastnikova, I.V. Alekseenko, A.I. Kuzmich, O.A. Bezborodova, E.R. Nemtsova, R.I. Yakubovskaya, E.D. Sverdlov, A.S. Sobolev, Nanostructures: Phys & Tech. 2013 Jun. Direct Link
Modelling the physics in the iterative reconstruction for transmission computed tomography. J. Nuyts, B. De Man, J.A. Fessler, W. Zbijewski, F.J. Beekman. Phys Med Biol. 2013 Jun. Pubmed Link
Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers, N. Kondo, T. Temma, Y. Shimizu, H. Watanabe, K. Higano, Y. Takagi, M. Ono, H. Saji, Cancer Science 2013 Apr, Pubmed Link
In Vivo Visualization and Quantification of (Disturbed) Oatp-Mediated Hepatic Uptake and Mrp2-Mediated Biliary Excretion of 99mTc-Mebrofenin in Mice, S. Neyt, M.T. Huisman, C. Vanhove, H. De Man, M. Vliegen, L. Moerman, C. Dumolyn, G. Mannens, F. De Vos, J Nucl Med. 2013 Apr. Pubmed Link
Monitoring Tumor Response to Linifanib Therapy with SPECT/CT Using the Integrin αvβ3–Targeted Radiotracer 99mTc-3P-RGD2S. Ji, Y. Zhou, M.J. Voorbach, G. Shao, Y. Zhang, G.B. Fox, D.H. Albert, Y. Luo, S. Liu, S.R. Mudd, J Pharmacol Exp Ther. 2013 Aug, Direct link
99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging, S. Ji, A. Czerwinski, Y. Zhou, G. Shao, F. Valenzuela, P. Sowiński, S. Chauhan, M. Pennington, S. Liu, Mol. Pharmaceutics 2013 Jul. Direct Link
Measles Virus Entry Through the Signaling Lymphocyte Activation Molecule Governs Efficacy of Mantle Cell Lymphoma Radiovirotherapy, Tanner S Miest, Marie Frenzke, Roberto Cattaneo, Mol Ther. 2013 Aug, Direct link
Development and characterization of [123I]-iodotiagabine for in vivo GABA-transporter imaging. O. Schijns, M. van Kroonenburgh, F.J. Beekman, J. Verbeek, J. Herscheid, K. Rijkers, V. Visser-Vandewalle, G. Hoogland., Nuc. Med. Communications, 2013 Feb. Pubmed Link
VECTor: A Pre-clinical Imaging System for Simultaneous Sub-mm SPECT-PET. M C. Goorden, F. van der Have, R. Kreuger, R.M. Ramakers, B. Vastenhouw, J.P.H. Burbach, J. Booij, F. J. Beekman. J.Nucl.Med., 2013 Feb. Pudmed Link
Monitoring Glioma Growth and Tumor Necrosis with the U-SPECT-II/CT Scanner by Targeting Integrin αvβ3, Shao G, Zhou Y, Wang F, Liu S. Mol Imaging 2013, Feb. Pubmed link
Performance evaluation of small-animal multipinhole μSPECT scanners, S. Deleye, R. Van Holen, J. Verhaeghe, S. Vandenberghe, S. Stroobants, S. Staelens, EJNMM  2013 Jan. Direct link
Effects of attenuation map accuracy on attenuation-corrected micro-SPECT images, C. Wu, H.A. van Andel, P. Laverman, O.C. Boerman and F.J. Beekman, EJNMMI Research 2013. Direct link
Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer. W. Bult , S. G.C. Kroeze (equal contributor), M. Elschot, P.R. Seevinck, F.J. Beekman, H.W.A.M. de Jong, D.R.A. Uges, J.G.W. Kosterink, P.R. Luijten, W.E. Hennink, A.D. van het Schip, J.L.H.R. Bosch, J.F.W. Nijsen, J.J.M. Jans (equal contributor). PLoS ONE. 2013 Jan. Direct link
Differential loading methods for BMP-2 within injectable calcium phosphate cement. F.C. van de Watering, J.D.M. Molkenboer-Kuenen, O.C. Boerman, J.J.J.P. Beucken, J.A. Jansen, J.D. Molkenboer-Kuenen, J.J. van den Beucken. Journal Of Controlled Release. 2012 Dec. Direct link
Quantifying the effect of repetitive transcranial magnetic stimulation in the rat brain by μSPECT CBF scans, T, Wyckhuys, N. de Geeter, G. Crevecoeur, S. Stroobants, S. Staelens, Brain Stimulation, 2012 Oct.  Pubmed link
Quantitative Immuno-SPECT Monitoring Of Pretargeted Radioimmunotherapy With A Bispecific Antibody In An Intraperitoneal Nude Mouse Model Of Human Colon Cancer. R. Schoffelen, W.T. van der Graaf, R.M. Sharkey, G.M. Franssen, W.J. McBride, Chien-Hsing Chang, D.L. Bos, D.M. Goldenberg, W.J. Oyen, O.C. Boerman. Journal Of Nuclear Medicine, 2012 Dec. Direct link
Radiolabeled Gelatin Type B Analogues Can Be Used For Non-Invasive Visualisation And Quantification Of Protein Coatings On 3D Porous Implants. K. Kersemans, T. Desmet, C. Vanhove, P. Dubruel, F. Vos. Journal Of Materials Science: Materials In Medicine, 2012 Aug. Direct link
Multiplexed Eighty Channel PMT List-Mode Data Acquisition System for 27-511 keV Gamma Ray Imaging, G. Tapias, J. L. Villena, R. Kreuger, E. Lage, F.J. Beekman, IEEE Trans. Nucl. Sci., 2012 Jun. Direct Link
In Vitro And In Vivo Characterization Of Three 68Ga- And 111In-Labeled Peptides For Cholecystokinin Receptor Imaging. L. Joosten, P. Laverman, O.C. Boerman, S. Roosenburg, A. Eek, F.P. Rutjes, F.L. van Delft. Molecular Imaging 2012 Sep. Direct link
Optimization of IGF-1R SPECT/CT Imaging Using 111In-Labeled F(ab’)(2) and Fab Fragments of the Monoclonal Antibody R1507. S. Heskamp, H.W.M. van Laarhoven, J.D.M. Molkenboer-Kuenen, W.H. Bouwman, W.T.A. van der Graaf, Wim J. G. Oyen, and Otto C. Boerman. Mol Pharm. 2012 Jul.  Pubmed link
Imaging of human epidermal growth factor receptor type 2 expression with 18F-labeled affibody molecule ZHER2:2395 in a mouse model for ovarian cancer. S. Heskamp, P. Laverman, D. Rosik, F. Boschetti, W.T.A. van der Graaf, W.J.G. Oyen, H.W.M. van Laarhoven, V. Tolmachev and O.C. Boerman. J Nucl Med. 2012 Jan. Pubmed link
Monitoring Breast Tumor Lung Metastasis by U-SPECT-II/CT with an Integrin αvβ3-Targeted Radiotracer 99mTc-3P-RGD2. Y. Zhou, G. Shao and S. Liu. Theranostics. 2012 Jun . Pubmed link
Evaluation of a technetium-99m labeled bombesin homodimer for GRPR imaging in prostate cancer. Z. Yu, G. Carlucci, H.J.K. Ananias, R.A.J.O. Dierckx, S. Liu, W. Helfrich, F. Wang, I.J. de Jong and P.H. Elsinga. Amino Acids. 2012 Jul. Pubmed link
18F-2-deoxy-2-fluoro-D-glucose positron emission tomography, computed tomography, and magnetic resonance imaging for the detection of experimental colorectal liver metastases. G.M. de Jong, T. Hendriks, R.P. Bleichrodt, H.M. Dekker, R.D. Mus, M. Gotthardt, E.P. Visser, W.j. Oyen and O.C. Boerman. Mol Imaging. 2012 Apr. Pubmed link
Multimerization improves targeting of peptide radiopharmaceuticals. G. Carlucci, H.J.K. Ananias, Z. Yu, C. Van de Wiele, R.A. Dierckx, I.J. de Jong and P.H. Elsinga. Current Pharmaceutical Design 2012. Pubmed link
Radiolabelled peptides for oncological diagnosis. P. Laverman, J. K. Sosabowski, O.C. Boerman, W.J.G. Oyen. Eur J Nucl Med Mol Imaging. 2012 Feb. Pubmed link
Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-annexin A5 in a Colorectal Cancer Xenograft Model. C. Vangestel ,C. van de Wiele, G. Mees, K. Mertens, S. Staelens, C. Reutelingsperger, P. Pauwels, M. van Damme, M. Peeters. Mol Imaging. 2012 Apr. Pubmed link
Fast Spiral SPECT with Stationary γ-Cameras and Focusing Pinholes. P.E.B. Vaissier, M.C. Goorden, B. Vastenhouw, F. van der Have, R. M. Ramakers, F.J. Beekman. J. Nucl Med. 2012 Aug. Direct link
99mTechnetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7–14) as a Targeted Imaging Agent with MicroSPECT in a PC-3 Prostate Cancer Xenograft Model. H.J. Ananias, Z. Yu, R.A. Dierckx, C. van der Wiele, W. Helfrich, F. Wang, Y. Yan, X. Chen, IJ de Jong, P.H. Elsinga. Mol. Pharmaceutics, 2011 Aug. Pubmed link
Evaluation of the radiation dose in micro-CT with optimization of the scan protocol. I. Willekens , N. Buls, T. Lahoutte, L. Baeyens, C. Vanhove, V. Caveliers, R. Deklerck, A. Bossuyt, J. de Mey. Contrast Media Mol Imaging. 2010 Jul. Pubmed link
Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats. C. Crunelle, T. Wit, K. Bruin, R. Ramakers, F. van der Have, F.J. Beekman, W. Brink, J. Booij. Nuclear Medicine and Biology. 2012 Jul. Direct link
Murine Cardiac Images Obtained With Focusing Pinhole SPECT Are Barely Influenced By Extra-Cardiac Activity”. W. Branderhorst, F. van der Have, B. Vastenhouw, M. Viergever, F.J. Beekman. Physics In Medicine And Biology. 2012 Feb.  Direct link
Predicting IGF-1R Therapy Response in Bone Sarcomas: Immuno-SPECT Imaging with Radiolabeled R1507. E.D.G. Fleuren, Y.M.H. Versleijen-Jonkers, A.C.M. van de Luijtgaarden, J.D.M. Molkenboer-Kuenen, S. Heskamp, M.H.S. Roeffen, H.W.M. van Laarhoven, P.J. Houghton, W.J.G. Oyen, O.C. Boerman and W. T.A. van der Graaf, Clin Cancer Res. 2011 Dec. Direct link
Molecular SPECT Imaging: An Overview, M.M. Khalil,  J.L. Tremoleda, T.B. Bayomy, W. Gsell.  Int J Mol Imaging. 2011 Apr. Pubmed link
Imaging of Prostate Cancer with Immuno-PET and Immuno-SPECT Using a Radiolabeled Anti-EGP-1 Monoclonal Antibody. C.M. van Rij, R.M. Sharkey, D.M. Goldenberg, C. Frielink, J.D.M. Molkenboer, G.M. Franssen, W.M. van Weerden, W.J.G. Oyen, O.C. Boerman. J. Nucl Med. 2011 Oct. Direct link
99mTc-(CO)3 His-Annexin A5 Micro-SPECT Demonstrates Increased Cell Death by Irinotecan During the Vascular Normalization Window Caused by Bevacizumab. C. Vangestel, C. van de Wiele, N. Van Damme, S. Staelens, P. Pauwels, C.P.M. Reutelingsperger, M, Peeters, J. Nucl Med. 2011 Nov. Direct link
Quantitative multi-pinhole small-animal SPECT: uniform vs. non-uniform Chang attenuation correction. C Wu, J.R. de Jong, H A Gratama van Andel, F. van der Have, B Vastenhouw, P. Laverman, O.C. Boerman, R.A.J.O. Dierckx,  F.J. Beekman. Phys Med Biol. 2011 Sep. Direct link
Image quality phantom and parameters for high spatial resolution small-animal SPECT.E.P. Visser, A.A. Harteveld, A.P.W. Meeuwis, J.A. Disselhorst, F.J. Beekman, W.J.G. Oyen, O.C. Boerman. Nucl. Instr. and Meth 2011 Oct. Direct link
Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat. Wyckhuys S. Staelens, B. Van Nieuwenhuyse, S. Deleye, H. Hallez, K. Vonck, R. Raedt, W. Wadman, P. Boon, NeuroImage. Pubmed Link
Absolute quantitative total-body small-animal SPECT with focusing pinholes. C. Wu, F. van der Have, B. Vastenhouw, R.A. Dierckx, A.M. Paans, F.J. Beekman,EJNM & Mol. Im. Pubmed link
Measurement of porto-systemic shunting in mice by novel three-dimensionalmicro-single photon emission computed tomography imaging enabling longitudinal follow-up, C. van Steenkiste, S. Staelens, S. Deleye, F. De Vos, S. Vandenberghe, A. Geerts, C. Van de Wiele, M. De Vos, H. Van Vlierberghe, I. Colle, LiverInt. Pubmed link
Accurate coregistration between Ultra-High-Resolution micro-SPECT and circular Cone-beam micro-CT scanners, C. Ji, F. van der Have, H. Gratama van Andel, R.M. Ramakers, F.J. Beekman, Int. J. Biomed. Imaging. Pubmed link
Radiolabeled cetuximab Dose optimization for EGFR imaging in a head-and-neck squamous cell carcinoma model, B.A. Hoeben, J.D. Molkenboer-Kuenen, W.J. Oyen, W.J. Peeters, J.H. Kaanders, J. Bussink, O.C. Boerman, Int. J. Cancer. Pubmed link
Targeted multi-pinhole SPECT. W. Branderhorst, B. Vastenhouw, F. van der Have, E. Blezer, W. Bleeker, F.J. Beekman. Eur J Nucl Med Mol Imaging. Direct link
Pixel-based subsets for rapid multi-pinhole SPECT reconstruction. W. Branderhorst, B. Vastenhouw, F.J. Beekman, Phys Med Biol. Direct link
ImmunoSPECT and ImmunoPET in IGF-1R Expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model, S. Heskamp, H.W. van Laarhoven, J.D. Molkenboer-Kuenen, G.M. Franssen, Y.M. Versleijen-Jonkers, W.J. Oyen, W.T. van der Graaf, O.C. Boerman, J. Nucl. Med. Pubmed link
High-resolution tomography of positron emitters with clustered pinhole SPECT, M.C. Goorden, F.J. Beekman, Phys. Med Biol. Pubmed link
Small-animal SPECT and SPECT/CT application in cardiovascular research. R. Golestani, C. Wu, R.A. Tio, C.J. Zeebregts, A.D. Petrov, F.J. Beekman, R.A. Dierckx, H.H. Boersma, R.H. Slart, Eur J Nucl Med Mol. Im. Pubmed link
In vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter, S. De Bruyne, L. Wyffels, T.L. Boos, S. Staelens, S. Deleye, K.C. Rice, F. De Vos, Nucl. Med. Bio. Pubmed link
In vitro and in vivo evaluation of 99mTc-labeled tricarbonyl His-annexin A5 as an imaging agent for the detection of phosphatidylserine-expressing cells. C. Vangestel, M. Peeters, R. Oltenfreiter, Y. D’Asseler, S. Staelens, M. Van Steenkiste, J. Philippé, D. Kusters, C. Reutelingsperger, N. Van Damme, C. Van de Wiele, Nucl. Med. Biol. Pubmed Link
Theoretical analysis of full-ring multi-pinhole brain SPECT. M.C. Goorden, M.C. Rentmeester, F.J. Beekman,. Phys. Med. Biol. Pubmed link
U-SPECT-II: An Ultra-High-Resolution Device For Molecular Small-Animal Imaging. F. van der Have, B. Vastenhouw, R.M. Ramakers, W. Branderhorst, J.O. Krah, C. Ji, S.G. Staelens, F.J. Beekman. Journal Of Nuclear Medicine. Direct link
Preclinical evaluation of monoclonal antibody 14C5 for the imaging of pancreatic cancer: in vitro and in vivo comparison of 125I-, 111In-DTPA- and 111In-DOTA-14C5, L. Vervoort, I. Burvenich, S. Staelens, C. Dumolyn, E. Waegemans, M. Van Steenkiste, S.K. Baird, A.M. Scott, F. De Vos, Cancer Biother Radiopharm.Pubmed link
Recent advances in small-animal cardiovascular imaging, B.M. Tsui, D.L. Kraitchman, J Nucl Med. Pubmed link
3-D Rat brain phantom for high resolution molecular imaging. Beekman et al. Proc. of the IEEE. Direct link
Effect of cyclosporin A administration on the biodistribution and multipinhole muSPECT imaging of [123I]R91150 in rodent brain.P. Blanckaert, I. Burvenich, S. Staelens, S. De Bruyne, L. Moerman, L. Wyffels, F. De Vos, Eur J Nucl Med Mol Imaging. Pubmed link
Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT. B. Vastenhouw, F. van der Have, A.J. van der Linden, L. von Oerthel, J. Booij, J.P. Burbach, M.P. Smidt, F.J. Beekman, Mol Psychiatry.Pubmed link
System calibration and statistical image reconstruction for ultra-high resolution stationary pinhole SPECT, F. van der Have , B. Vastenhouw, M. Rentmeester, F.J. Beekman, IEEE Trans Med Imaging. Pubmed link
Optimizing multi-pinhole SPECT geometries using an analytical model. M. Rentmeester, F. van der Have, F. Beekman, Phys Med Biol. 2007 May. Pubmed Link
The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging. F.J. Beekman, F. van der Have, Eur J Nucl Med & Mol Im. Pubmed link
Multi-modality imaging on track, F.J. Beekman, B.F. Hutton, Eur J Nucl Med Mol Imaging.Pubmed link
U-SPECT-I: A Novel System for Submillimeter-Resolution Tomography with Radiolabeled Molecules in Mice, F.J. Beekman, F. van der Have, B. Vastenhouw, A.J. van der Linden, P.P van Rijk, J.P. Burbach, M.P. Smidt. J Nucl Med. Pubmed link

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