Meeting the challenge of quantitative radio-therapy SPECT imaging with 188Re
Rhenium-188 (188Re) is arguably the most promising generator-produced beta-emitting radionuclide for radiotherapy applications. With a beta-energy of 2.12 MeV (100%) and medium-short half-life of 17h, it is readily available using commercially available generators and has a similar chemistry and gamma emission peak (155 keV, 15%) to 99mTc.
Unfortunately, the accurate image quantitation of 188Re over a wide range of activities for dosimetric purposes remains a challenge. Quality of 188Re images obtained with traditional preclinical multi-pinhole SPECT imagers is significantly worse than for 99mTc, resulting from the presence of scattered photons and collimator aperture penetration from high-energy gamma rays up-to 913 keV.
In this scientific publication, the authors describe that MILabs VECTor system enables for the first time, to obtain images of similar quantitative accuracy and resolution as can be obtained by imaging 99mTc.
Selected Scientific Publication
188Re image performance assessment using small animal multi-pinhole SPECT/PET/CT system
Esquinas et al.,
Physica Medica 2016
Coronal slices of the fused SPECT/CT mouse scans showing the biodistribution of 188Re-microspheres.
MILabs’ high-resolution VECTor/CT system is used to:
Produce high-quality, statistically-robust images at sub-mm resolutions.
Provide reliable quantification over a wide dose-range enabling good treatment planning and accurate therapy dosimetry calculations.
Eliminate image distortion effects caused by the presence of high-energy 188Re gammas through the use of VECTor’s proprietary clustered pinhole apertures.
Enabling to accurately optimize tumor-to-normal organ dose ratios for fast translation of promising compounds into the clinic.
Confirm that 188Re complexes, which exhibit similar synthetic approaches as 99mTc, show indeed the same biodistribution.
Demonstrate the unique ability of MILabs’ VECTor to image high-energy theranostic isotopes such as 131I, 213Bi and 188Re with high sensitivity and high resolution. See Related Publications.
Y. Chao, et al., Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-sensitized, Near-infrared Enhanced Radioisotope Therapy, Small 12, 3967–75, 2016. Pubmed Link
R. Lange, et al., Drug Composition Matters: The Influence of Carrier Concentration on the Radiochemical Purity, Hydroxyapatite Affinity and in-Vivo Bone Accumulation of the Therapeutic Radiopharmaceutical (188)Rhenium-HEDP, Nuclear Medicine and Biology 42: 465–69, 2015 Pubmed Link
R. ter Heine, et al., Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases., Int. J. Pharmaceutics 465, 317-24, 2014 Pubmed Link
J. de Swart, et al. Utilizing High-Energy γ-Photons for High-Resolution Bi-213 SPECT in Mice, J Nucl Med 57, 486-92, 2016 Pubmed Link
F. van der Have, et al. High-resolution clustered pinhole I-131 SPECT imaging in mice, Nuclear Medicine and Biology 43, 505-11, 2016 Pubmed Link
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