Ultra-high resolution imaging of high-energy SPECT tracers enables theranostic imaging and quantification
Accurate radio-theranostic imaging is becoming more and more important in both preclinical and clinical studies. Until now, only nuclear tracers with energies up to 350 keV could be used for quantitative SPECT imaging. MILabs’ new Stationary Clustered Pinhole (SCP) SPECT makes it now possible to image nuclear tracers up to 600 keV. This dramatically expands the application field of preclinical imaging for theranostic research: high-energy therapeutic tracers can be imaged directly; the dynamic behavior of radio-therapeutics can be studied; list-mode data enables post-acquisition dose optimization; and above all, the simultaneous acquisition of both SPECT and PET tracers makes it possible to obtain target specific information as well as to assess diseases treatment endpoints.
The authors of this publication demonstrate that the MILabs’ VECTor PET/SPECT/CT system can obtain images at sub-mm resolution in mice using low-dose 213Bi-labeled octreotate to trace and quantify radioactive uptake in tumor xenografts at sub-mm resolution.
Utilizing high-energy gamma photons for high-resolution 213Bi SPECT in mice
de Swart et al., J. Nucl. Med., 2015
This publication utilizes the MILabs VECTorTM imaging system to:
Use the 440 keV gamma-rays instead of the 79 keV X-rays, which strongly improves image resolution.
Quantify radio-theranostic effects with reliable activity recovery at activity levels as low as 0.240 MBq/mL within 30 minutes.
Quantify the in vivo uptake data, thus enabling kinetic modeling, and estimation of absorbed dose into kidneys.
Perform high-resolution high-energy imaging at <0.7 mm resolution with excellent contrast-to-noise ratios.
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