In-Vivo Optical Imaging: the coming of age of a technology

In vivo diffuse optical imaging of small animals has been employed for over 20 years. In-spite of the advantages offered by optical imaging such as wide availability of optical reporters and probes, accurate in vivo optical imaging suffers from a major obstacle; light scattering in tissues. This results in strong signal attenuation and loss of directionality, making optical imaging unsuited for deep-tissue and high-resolution quantitative imaging. By using a new technique, called X-ray CT-guided Optical imaging, MILabs has been able to eliminate most of these shortcomings of in vivo optical imaging.In vivo diffuse optical imaging of small animals has been employed for over 20 years. In-spite of the advantages offered by optical imaging such as wide availability of optical reporters and probes, accurate in vivo optical imaging suffers from a major obstacle; light scattering in tissues. This results in strong signal attenuation and loss of directionality, making optical imaging unsuited for deep-tissue and high-resolution quantitative imaging. By using a new technique, called X-ray CT-guided Optical imaging, MILabs has been able to eliminate most of these shortcomings of in vivo optical imaging.

Since the introduction of MILabs’ Hybrid OI/CT system in 2018, many novel user applications for optical imaging have emerged. As illustrated above, the technology enhances translational in vivo imaging by providing quantitative 3D images. Please check out the following application examples on our website:

• CT-guided Fluorescence Tomography (FLT/CT) for accurate biodistribution in deep tissues
• Direct one-to-one translation of Optical to Nuclear PET and/or SPECT:
• Dual-use CT for Intracranial Optical Tomography & Brain Angiography
• Single-pass Hybrid Optical-PET biodistribution for Surgical Guidance
• 3D fluorescence tomography for studying nanomedicine enhancement
• The only Optical Imaging system including cutting-edge in vivo diagnostic CT
• MILabs exclusive Duet Optical Imaging module: two functionalities in one

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