3D Autoradiography for research
Reveal precise molecular distributions in intact tissue so you can generate high-confidence, quantitative insight beyond the limits of conventional autoradiography.
3D Autoradiography enables high-resolution, ex vivo visualization and quantification of radiotracer distributions in intact samples. By reconstructing volumetric datasets rather than relying on thin tissue sections, researchers gain clearer spatial context, improved accuracy, and stronger translational relevance for molecular imaging studies.
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EXIRAD-3D: automated 3D Autoradiography
Eliminate manual sectioning, reduce variability, and capture true 3D molecular detail with confidence. With EXIRAD-3D, researchers benefit from:
- EAutomated, quantitative 3D Autoradiography of intact tissue and whole organs
- EUltra-high spatial resolution down to 0.12 mm for detailed molecular localization
- ESimultaneous multi-isotope imaging enabled by excellent energy resolution
- EStreamlined workflows that remove time-consuming and error-prone manual reconstruction
- EFlexible digital re-slicing for multi-angle tissue analysis and interpretation
- EAvailable for U-SPECT, U-SPECT/CT, VECTor, and VECTor/CT platforms
Find out how other researchers are using this technology
Integrate EXIRAD-3D with anatomical CT
Add anatomical context to molecular distributions without sacrificing precision.
When combined with ultra-high-resolution CT, EXIRAD-3D enables accurate overlay of molecular autoradiography data with anatomical structures. This integration improves localization, interpretation, and confidence in tissue-level analysis, supporting deeper insight into biological systems and tracer behavior.
Hear from the experts
EXIRAD 3D autoradiography for neurology
“This new PET/SPECT/CT instrument combined with EXIRAD- 3D automated autoradiography will facilitate our research of cerebral blood flow and its glial regulation. As a result, disorders long thought neuronal in nature can now be investigated as disorders principally of glial cells, including both astrocytes and oligodendrocytes, as well as their progenitors.”
FAQ
How does EXIRAD-3D work?
EXIRAD-3D uses a small-bore, multi-pinhole focusing collimator mounted on a U-SPECT system with stationary detectors. An integrated tissue cooling system preserves sample integrity and prevents activity migration during scanning.
What are the benefits of EXIRAD-3D?
Researchers gain faster and more reliable 3D Autoradiography with significantly higher resolution than conventional microSPECT-based approaches while avoiding the complexity of manual slice reconstruction.
Should I use microSPECT or 3D Autoradiography?
Both approaches provide 3D insight, but they serve different goals. Traditional autoradiography can achieve extremely high spatial resolution, but it typically requires tissue sectioning and a time-consuming manual reconstruction workflow that can introduce deformation and alignment errors. EXIRAD-3D is designed to make 3D Autoradiography faster and more consistent, by scanning intact, cryo-cooled samples and generating a full 3D reconstruction without manual slicing, photographing, or stacking. The right choice depends on whether you need in vivo dynamics (microSPECT) or efficient, high-quality ex vivo 3D tissue mapping with less workflow burden (EXIRAD-3D).