Ultra-High-Sensitivity SPECT for Ultra Low Dose Imaging
A recent publication in the Journal of Nuclear Medicine highlights impressive image quality even at extreme low dose (0.25 MBq) with MILabs U-SPECT equipped with a special collimator. The same collimator allows for extremely fast SPECT (1 second time iframes). This opens up new possibilities for screening tracers with initially very low yield, imaging of extremely low receptor densities and/or dynamic imaging of fast tracer kinetics. With the same system, record-resolution SPECT images down to 0.25 mm can be acquired as well.
|In 3.5-MBq scan, high level of anatomic detail is provided in for instance skull and pelvis. In 0.25-MBq scan, still show high level of detail. Read entire paper here|
|Slices of dynamic 15-s frames for dual-isotope 99mTc-MAG3 (green) and 111In-DTPA (orange) kidney scan (time delay between injections was 45 s). Images illustrate difference in tracer dynamics, with slower uptake/clearance and longer plateau for 99mTc-MAG3 than for 111In-DTPA. Time–activity curves of 111In-DTPA/99mTc-MAG3 uptake by left and right kidneys. Read entire paper here|
|These images clearly show separation between left and right ventricular walls, as well as details of myocardial structure. Time–activity curves visualize 1-s time resolution tracer dynamics in aorta and myocardial tissue. Read entire paper here|
|Side and top views on maximum intensity projections of a mouse 99mTc-MDP total body SPECT scan. Read entire paper here|