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| Spectral and Confocal Ultra-High Definition PET paves the way for highly improved and unique imaging experiments |
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Today’s newsletter is about the rapidly growing unique applications of MILabs’ U-PET, and VECTor PET-SPECT, enabled by positron-range free imaging, spectral and magnifying confocal capabilities, plus scatter and random rejection, as shown in recently published physics experiments and application examples.
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| Bringing Confocal Imaging to PET scanning for sharper, translatable images |
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Confocal configuration with Spectral PET scan |
Why is it that traditional preclinical PET is not using confocal scanning techniques? To improve translational power, it seems essential that mouse PET scans have the same visual acuity as human PET scans. Today’s mouse scans at about 1 mm correspond to >15 mm resolution human PET scans. Hardly acceptable. The need for sharper images is as compelling as in microscopy, where confocal microscopes have since long replaced wide-field configurations. Similarly, confocal PET scanning rejects out-of-field and unwanted noise sources and delivers nearly 10-fold improved volumetric resolution for 18F. We call it U-PET, for Ultra-High-Definition PET. No randoms, less background scatter, sharper images, better accuracy, and superior translatable data. Read more
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| Spectral PET to extend imaging capabilities beyond traditional PET |
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Simultaneous sub-mm 18F & 124I PET |
U-PET is not just about getting sharper pictures. While one mm resolution can be achieved for 18F in wide-field traditional PET using specific resolution-recovery software techniques, many popular PET isotopes such as 89Zr, 124I, 76Br, and 82Rb offer poor-quality images due to positron-range blurring. Not so with U-PET imaging. Rather than relying on the single energy of coincident photons for reconstructing images, U-PET’s spectral capabilities provide a wealth of information carried by billions of prompt photons of PET tracers, which in contrast to annihilation photons, are not affected by positron range blurring. The result: sub-mm resolution for almost all PET isotopes, plus spectral PET capabilities which enable to image multiple PET tracers simultaneously, and eliminate scatter, as recently featured in Physics World of 5 March 2021.
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| Now you can discover what never has been seen before |
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Hetero-tumor and dengue virus imaging |
Sometimes, one cannot see it with traditional PET, but one knows that it exists. One example is the tumor microenvironment’s immune landscape. Try to image heterogeneous uptake with 89Zr immunoPET: only U-PET can. Read more
Another example is the diagnosis and radiotherapy of hypoxic tumors. With a single scan, 64Cu-ATSM and 99mTc-HSA will illustrate Auger electron radiotherapy’s effect on both tumor vascularity and hypoxia. Read more
Plus, there are many more applications, including quantifying 18F-FDG uptake in dengue virus-infected small intestines, high-energy alpha therapy, whole-body dynamic PET, even early detection of pancreas cancer insensitive to 18F-FDG uptake. Read more
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| Making isotope translation easy from diagnostics to theranostics |
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One-to-one SPECT -> PET -> Theranostic |
Never before has it been so straightforward to translate research from diagnostics to targeted theranostics applications. In the same animal, Spectral capabilities of VECTor U-PET/U-SPECT allows to compare PET, SPECT, and theranostic isotopes under the same physical and physiological conditions – with not only spatial but also temporal co-registration. This enables researchers to enhance and increase the information content that may be gleaned during preclinical in-vivo imaging studies while it makes possible a one-to-one translation of different isotope tracers with one single scan. Easy, accurate, and efficient. Read more
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| Stability, reliability, and low acoustic noise |
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In terms of laboratory usage, a clear advantage of U-PET is the lack of acoustic background noise, high tolerance for temperature changes offering the possibility to operate the equipment over a wide range of lab temperatures, and field-proven excellent system reliability and stability.
Besides U-PET’s unique imaging capabilities, these are critical factors that can determine research success and prevent unexpected work disruptions.
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| From small to large animals to efficiently bridge the translational gap |
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Clinical bore, same technology with sharp images |
With the recent introduction of a large-bore PET, SPECT, and Theranostics imaging system, MILabs ensures the translation continuum from bench to clinic. Certification for human imaging of the large-bore system is in progress. Again, Confocal & Spectral PET imaging capabilities make this system unique: up to ten-fold improvement in resolution, up to twenty times reduction in dose, simultaneous PET/PET, PET/SPECT, and PET/Theranostic imaging. Translational workflow at its best. Read more
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| U-PET/CT: Spectral PET + Spectral CT for exceptional results |
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Mouse whole-body angiography at two energies |
Never before has the power of spectral imaging being combined within a single molecular CT system for preclinical imaging. Now think about the possibilities. You can expand precision diagnostics with detailed molecular and morphological information and select, at the highest possible resolution, the most relevant molecular tracer, whether PET, SPECT and even 3D Optical if desired. Better yet, you can match your diagnostic results with targeted theranostics, using virtually any alpha and beta radiotherapy isotope. All on a simple to use system, with a single pass of the animal. Read more
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| Job Openings to support MILabs’ accelerating growth |
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With a compounded annual growth rate of nearly 50% since 2018, MILabs seeks talented individuals to further scale-up its organization and to strengthen the support of its customers and industry collaborators.
We are searching for:
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