Scientific Publications: Multi-Modal Nano-Theranostics Imaging

Multi-Modal Nano-Theranostics Imaging

This application note highlights the process of designing ultra-small nanoparticles for multi-modal theranostics applications. Researchers at the University of Soochow have succeeded in designing a single entity theranostic agent with the right ratio of multi-modal diagnostic and therapeutic components in a very small, sub-3 nm nanodot composite. In addition to featuring improved biocompatibility and lower cytotoxicity, these ultra-small Bi₂Se₃ nanodots exhibit excellent performance for photoacoustic imaging and photothermal therapy and offer great potential for CT imaging and radiation therapy enhancement. Moreover, labeling with ^99mTc and ¹⁸⁸Re (as documented in a related publication) enables radioisotope diagnostics and therapy. MILabs ultra-high resolution multi-modal SPECT/CT system was used for in vivo biodistribution imaging and quantitation.

Selected Scientific Publication

Summary

MILabs’ high-resolution U-SPECT/CT system is used to:

• Quantitate in vivo biodistribution and assess toxicity.
• Reveal the dynamic behavior of the agent during 24h.
• Analyze potential for using combined radioisotope and radiation therapy.
• Study the efficiency of in vivo delivery to the lesion site(s).

Related Publications

• Shaohua Zhang, et al., Ambient Aqueous Synthesis of Ultra-small PEGylated Cu2-xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer, Adv Mater., 28, 8927–36, 2016
• Yu Chao, et al., Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-sensitized, Near-infrared Enhanced Radioisotope Therapy, Small, 12, 3967–75, 2016
• Ling Wen, et al. Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers, Adv Mater. 28, 5072–79, 2016