This application note highlights the process of designing ultra-small nanoparticles for multi-modal theranostics applications. Researchers at the University of Soochow have succeeded in designing a single entity theranostic agent with the right ratio of multi-modal diagnostic and therapeutic components in a very small, sub-3 nm nanodot composite. In addition to featuring improved biocompatibility and lower cytotoxicity, these ultra-small Bi2Se3 nanodots exhibit excellent performance for photoacoustic imaging and photothermal therapy and offer great potential for CT imaging and radiation therapy enhancement. Moreover, labeling with 99mTc and 188Re (as documented in a related publication) enables radioisotope diagnostics and therapy. MILabs ultra-high resolution multi-modal SPECT/CT system was used for in vivo biodistribution imaging and quantitation.
Selected Scientific Publication
Ultra-Small Biocompatible Bi2Se3 Nanodots for Multimodal-Imaging-Guided Synergistic Radio-Photothermal Therapy against Cancer
Mao et al.,
ACS Nano 2016
SPECT imaging demonstrates quantitative in vivo biodistribution during 24h after injection of nanodots.
MILabs’ high-resolution U-SPECT/CT system is used to:
Quantitate in vivo biodistribution and assess toxicity.
Reveal the dynamic behavior of the agent during 24h.
Analyze potential for using combined radioisotope and radiation therapy.
Study the efficiency of in vivo delivery to the lesion site(s).
Shaohua Zhang, et al., Ambient Aqueous Synthesis of Ultra-small PEGylated Cu2-xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer, Adv Mater., 28, 8927–36, 2016
Yu Chao, et al., Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-sensitized, Near-infrared Enhanced Radioisotope Therapy, Small, 12, 3967–75, 2016
Ling Wen, et al. Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers, Adv Mater. 28, 5072–79, 2016