Scientific Publication: Nanomedicine carriers imaging by high-sensitivity SPECT

In vivo biodistribution of stable
spherical and filamentous micelles
probed by high-sensitivity SPECT

Understanding how nanoparticle properties such as size, morphology and rigidity influence their circulation time is essential for the development of effective nanomedicine diagnostics and therapies.  In this study, the authors demonstrate for the first time that non-invasive longitudinal quantitative SPECT can be used to study the effects of shape, size and rigidity of nanoparticles on their circulation time, general biodistribution and clearance in vivo.

This application is made possible by the high sensitivity and quantitative imaging capabilities of MILabs’ SPECT/CT system. This enables the simple physical encapsulation of radioisotopic markers into nanocarriers with vastly different morphologies, thus avoiding costly formulation efforts without having to alter the surface properties of the carriers.

Scientific Publication

Summary

This publication utilizes the MILabs imaging system to:

• Perform detailed quantitative longitudinal in vivo SPECT imaging.
• Measure the biological effect of shape, size and rigidity of nanoparticles  in vivo.
• Acquire in vivo dynamic biodistribution data.
• Greatly reduce the number of animals needed for analysis.
• Demonstrate the great versatility of this theranostic device approach for research purposes.