Scientific Publication: Concurrent 64Cu and 99mTc imaging

Exploiting the advantages of Concurrent PET/SPECT:
In vivo SPECT/PET/CT imaging with ^99mTc-HSA (vascularity) and ⁶⁴Cu-ATSM (hypoxia)

In vivo examination of vascularity and hypoxia in tumors is important in understanding cancer biology and for the development of therapeutic strategies. It’s becoming apparent that cancer treatment may need advanced strategies by e.g. combining antiangiogenic, antivascular, and antihypoxia therapies. For the first time, it’s now possible to image and quantitate the combined effect of such therapies with single in vivo imaging sessions.

The authors of this publication demonstrate this innovation in cancer imaging by using the MILabs’ VECTor PET/SPECT/CT system to clearly distinguish ^99mTc-HSA uptake regions (blood pool) and ⁶⁴Cu-ATSM uptake regions (hypoxia) in a HT29 xenograft, with both tracers being imaged at exactly the same time.

Scientific Publication

Summary

This publication utilizes the MILabs VECTor^TM imaging system to:

• Perform concurrent in vivo PET and SPECT imaging.
• Quantitate simultaneously acquired ⁶⁴Cu and ^99mTc images.
• Exploit virtually unlimited combinations of PET and SPECT tracers.
• Explore single and dual tracer imaging over a wide linear response range.