Reaching Higher Levels of Performance with In-vivo SPECT
Reaching Higher Levels of Performance with In-vivo SPECT
Requirements for preclinical SPECT imaging applications range from fast whole-body acquisitions to visualizing and quantifying uptake in tiny structures within tumors and organs. MILabs U-SPECT has been in continual development over the past decade to meet all these needs. Advances achieved with U-SPECT have been so momentous that some users have dubbed it “the next revolution in resolution”.
Superior Resolution-Sensitivity Tradeoff
Highly magnified pinhole collimation combined with ultra-large & efficient detectors has been proven to provide the highest resolution and sensitivity in SPECT. As illustrated by the sensitivity vs resolution graphs of three commercial preclinical systems, U-SPECT offers a 3 to 30 times better sensitivity at equal resolution. Correspondingly, the resolution of U-SPECT is far superior. As a result, U-SPECT can be used to detect tiny lesions and to produce great images with only tiny amounts of tracers. The superior sensitivity combined with stationary detection furthermore provides unprecedented high frame rates (4D-SPECT) as well as outstanding throughput. Interestingly, these advances over other systems are amplified when imaging high-energy gammas from, e.g., theranostic isotopes – a unique additional capability enabled by MILabs’ proprietary M7™ stationary cluster pinhole technology.
Ultra-Fast & Detailed 4D Cardiac SPECT in Mice
MILabs’ dual-gated U-SPECT imaging can visualize highly localized tissue functions in rodent hearts not detectable with any other imaging device. It allows cardiac researchers to image, track, and quantify molecular biomarkers in tiny heart structures of fast- beating atrial and ventricular wall sub-sections. Thanks to U-SPECT, every cardiac imaging test available for humans can be performed in mice, whether using 99mTc,201Tl, 111In or 82Rb tracers. Add detailed structural information to the same scan (on, e.g. coronaries) by combining this with MILabs’ integrated ultra-high resolution 4D CT. Click here for more information.
An Innovative Force in Musculoskeletal Imaging
The ability of MILabs U-SPECT to image small bone structures at resolutions of 0.12 mm ex-vivo and 0.25 mm in-vivo is a breakthrough for the molecular detection of the underlying causes of musculoskeletal diseases such as arthritis. Only a few years ago, such an advancement in nuclear imaging appeared futuristic. Click here for more information.
Large-Scale Functional Imaging of Small Brains
With ever-increasing understanding of a mouse’s genetic profile, brain research is shifting to the lab mouse. The limited spatio-temporal resolution of nuclear imaging devices often forced researchers to use rats in order to differentiate various small brain structures. As illustrated, U-SPECT allows the relevant structures to be imaged in mice, such as the kinetics and function of the striatum as well as the tiny olfactory bulb. Moreover, the unique 4D CT capabilities of U-SPECT/CT make this neuromics platform suitable for rapid qualitative and quantitative evaluation of mouse cerebral physiology and pathology – including detailed structural information. Click here for more information.
Elucidating Treatment Efficacy in Tumor Model
Drug delivery into tumors remains a challenge. Determining the effective dose of therapeutics to be delivered to cells within a tumor often produces results with high variability, largely because of tumor heterogeneity due to e.g. its vascular network, MILabs’ U-SPECT allows visualization of the efficiency of immunotherapy and oncologic virotherapy in mouse tumors with an ultra-high resolution of 0.25 mm. Moreover, it allows the effect of nanomedicine accumulation due to EPR changes to be studied using clinically relevant pharmacological and physical co-treatments. For further reading, click here.
Whole-Body Dynamic SPECT Pharmacokinetics
Dynamic studies – once the privileged domain of PET – can now be performed with MILabs’ U-SPECT. Acquiring tomographic SPECT-images without detector rotation allows organ kinetic studies with a time resolution of 1 second, and whole-body dynamic acquisitions with a time resolution <10 seconds. For more information, click here. MILabs U-SPECT stationary geometry is stable for many years – the best way to guarantee reproducibility of longitudinal studies. Fast and precise, without gantry wear-and-tear and without detector positioning inaccuracies.
SPECT for Preclinical, PET for Clinical? No Problem
Resolution, cost and simplicity are a few of the advantages when developing preclinical applications with SPECT. For clinical applications, however, PET is often preferred. Fortunately, as illustrated now by many users, the concurrent SPECT/PET option of MILabs’ U-SPECT allows the user to switch tracers from SPECT to PET and image them in the same animal at the same time – resulting in images that are acquired under identical physical and physiological conditions and that are co-registered in both space and time. The same single-step process also applies to theranostic tracers for radiotherapy applications, as illustrated in this presentation.
Need a High Throughput? Image Four Mice at a Time
A special mouse-rat collimator allows you to image four mice simultaneously, using both SPECT and CT. Potential resolution blurring – even when imaging multiple isotopes simultaneously – is eliminated by applying a proprietary respiratory gating approach.
Job Openings to Support MILabs’ Accelerating Growth
With a compounded annual growth rate of nearly 50% since 2018, MILabs seeks talented individuals to further scale-up its organization and to strengthen the support of its customers and industry collaborators.