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How MILabs’ HD-PET boosts performance and extends applications of small animal PET

While clinical coincidence-based PET instrumentation has advanced over the last ten years through time-of-flight (TOF), flow motion and whole-body imaging to improve image quality, small animal PET has not made the same strides. The huge size difference between men and mice constitutes formidable challenges for preclinical coincidence PET, where the physical limitations of scaling-down detection systems affect image quality.

Crisp and sharp preclinical PET images require new approaches. Not unlike the switch to HD-TV, high definition PET (HD-PET) requires high resolution combined with high signal-to-noise. Don’t be left behind. Join your peers by adapting HD-PET and look at the following examples. You may appreciate the impact HD-PET could have on your preclinical research.
 
“The resolution and sensitivity of MILabs HD-PET are exquisite. For instance, we are capable of running dynamic PET at high temporal and spatial resolution with low <5MBq activity levels, while tumor heterogeneity can still be observed with only 0.01MBq delivered to the tumor” (The impact of HD-PET on their research, Lead Biological Scientist at Oxford University)

 

18F resolution of 0.6 mm; No positron range blurring for 124I and 82Rb

With its uniform and unprecedented high spatial resolution, HD-PET provides researchers details of tracer uptake in tiny tissue structures that cannot be recovered using coincidence PET. Image blurring effects resulting from finite detector resolution and depth-of-interaction are dramatically reduced by image demagnification. Moreover, high-energy PET isotopes such as 124I and 82Rb can be imaged at sub-mm resolution, without devastating positron range induced blurring that is inherent to other PET systems.

 

Noise reduction by elimination of random coincidences and scatter

 

MILabs VECTor HD-PET inherently eliminates noise and bias from random-coincidences and to a large extent also from scatter. For the same activity levels and acquisition times, VECTor HD-PET can often provide much better small lesion contrast and organ imaging. 

– Walker et al, J Nucl Med., 2014

 

Whole-body dynamic VECTor HD-PET at low doses

This example of a dynamic whole-body biodistribution image, obtained with just 1.4 MBq of activity, is from one of the many papers underscoring total body dynamic PET capabilities of  VECTor. Throughout the entire selected whole-body field-of-view (FOV), images are clear and uniform.

– Verhoog et al. J Am Chem Soc, 2018
Wilson et al, J Nucl. Med, 2019

 

SPECT option enables simultaneous PET & SPECT imaging

With its unique SPECT option, VECTor can not only image at quarter-mm resolution in vivo but also allows simultaneous PET & SPECT. This unique tool for studying molecular mechanisms and pathways under exactly the same physical and physiological conditions was shown to be very usefull at Oxford by simultaneous 89Zr-antibody PET and isotope-matched non-specific 111In-IgG SPECT to measure differences in non-specific tumor uptake for true quantification of epitope expression levels. Several other groups have also shown interesting applications of simultaeneous VECTor PET-SPECT in oncology, cardiology and brain research.

– Knight et al, Nucl. Med. Biol., 2019
– Goorden et al, J Nucl. Med, 2013

– Adachi et al, IJSBAR, 2016

 

Simultaneous multi-isotope PET imaging

VECTor HD-PET enables imaging of PET isotopes such as 124I and 82Rb at sub-mm resolution, without positron range-induced blurring that is inherent to other PET systems. Moreover, these isotopes can be imaged simultaneously with PET isotopes like18F. Using VECTor HD-PET, one can simultaneously assess e.g. tumor biology with 124I-immunoPET and 18F-FDG or correlate cardiovascular 82Rb-PET perfusion with  18F-FDG metabolism.

– WMIS publications, 2018

 

Exclusive sub-mm alpha and beta radiotherapy imaging

MILabs VECTor HD-PET can image high-energy photons, the system has the unique capability to image alpha and beta emitters for cancer therapy such as 213Bi, 131I, or 225Ac. These capabilities to image these radiotherapy tracers at sub-mm resolutions greatly expands possibilities for theranostics research.

– De Swart et al, J Nucl Med, 2016
– Crawford et al, Phys Med Biol 2018

– Van der Have et al, Nucl Med Biol 2016

 

Entering a new world of imaging capabilities

Some unique capabilities of HD-PET are summarized in above table. This best-in-class PET is part of MILabs expandable U-PET as well as MILabs award-winning VECTor-6 Broad Band Photon Tomography platform (WMIC 2018 Innovation of the Year). This scalable multi-modality platform includes fully integrated HD-PET, SPECT, Optical, and CT tomography capabilities enabling 3D & 4D imaging of photons from 1 eV to 1 MeV.

Watch the complete video of the 6-series VECTor platform.

 

Meet us at:

BMIC, April 23, Brussels
ISRS, May 26 – 31, Beijing
SNMMI, June 22 – 25, Anaheim
WMIC, September 4-7, Montreal
EANM, October 12-16, Barcelona

 

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