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Simultaneous SPECT imaging of neurotransmitter systems in the brain

by Dr. Kelly Ceyzériat, Hôpitaux Universitaires de Genève – Belle-Idée, Switzerland

Dopaminergic system is involved in many behavioral and cognitive functions and appears more and more implicated in neurological diseases. The U-SPECT imaging system allows us to estimate both the density and the affinity of dopaminergic receptors in the striatum and also in the SN/VTA. Moreover, using dual injections of radiotracers, U-SPECT imaging allows us to study two neurotransmitter systems in a single acquisition and consequently evaluate the interaction between them.
To conclude, these approaches will make it possible to measure in vivo neurotransmitter system alterations in preclinical models and to evaluate the response to treatment.

Took place: October, 2020

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