Simultaneous SPECT imaging of neurotransmitter systems in the brain

by Dr. Kelly Ceyzériat, Hôpitaux Universitaires de Genève – Belle-Idée, Switzerland

Dopaminergic system is involved in many behavioral and cognitive functions and appears more and more implicated in neurological diseases. The U-SPECT imaging system allows us to estimate both the density and the affinity of dopaminergic receptors in the striatum and also in the SN/VTA. Moreover, using dual injections of radiotracers, U-SPECT imaging allows us to study two neurotransmitter systems in a single acquisition and consequently evaluate the interaction between them.
To conclude, these approaches will make it possible to measure in vivo neurotransmitter system alterations in preclinical models and to evaluate the response to treatment.

Took place: October, 2020

Back to all webinars

You may also like

Hoffman Memorial Lecture
Lecture at Freek Beekman’s receipt of the Hoffman Memorial Award at the 2017 Society of Nuclear Medicine and Molecular Imaging.
Making hypoxic metabolism visible for 64Cu-ATSM treatment using simultaneous PET/SPECT imaging
Exploit simultaneous 99mTc-HSA/64Cu-ATSM imaging to accelerate the development of 64Cu-ATSM as an add-on targeted radiotherapy agent.
MILabs USPECT4CT: applications in a preclinical study of 212Pb alpha radioimmunotherapy in multiple myeloma
This webinar highlights the potency of 212Pb-alpha radioimmunotherapy in Multiple Myeloma treatment. The results of this study showed the efficacy of 212Pb-daratumumab in xenografted mice with significant tumor regression and increased survival.
Scroll to Top